IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v6y2015i1d10.1038_ncomms8138.html
   My bibliography  Save this article

Genome-wide association study of colorectal cancer identifies six new susceptibility loci

Author

Listed:
  • Fredrick R. Schumacher

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Stephanie L. Schmit

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
    Keck School of Medicine, University of Southern California)

  • Shuo Jiao

    (Fred Hutchinson Cancer Research Center)

  • Christopher K. Edlund

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Hansong Wang

    (Epidemiology Program, University of Hawaii Cancer Center)

  • Ben Zhang

    (Third Military Medical University Southwest Hospital)

  • Li Hsu

    (Fred Hutchinson Cancer Research Center)

  • Shu-Chen Huang

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Christopher P. Fischer

    (University of Michigan Comprehensive Cancer Center)

  • John F. Harju

    (University of Michigan Comprehensive Cancer Center)

  • Gregory E. Idos

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Flavio Lejbkowicz

    (Carmel Medical Center
    Clalit Health Services National Cancer Control Center)

  • Frank J. Manion

    (University of Michigan Comprehensive Cancer Center)

  • Kevin McDonnell

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Caroline E. McNeil

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Marilena Melas

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Hedy S. Rennert

    (Carmel Medical Center
    Clalit Health Services National Cancer Control Center)

  • Wei Shi

    (Children’s Hospital Los Angeles)

  • Duncan C. Thomas

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • David J. Van Den Berg

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Carolyn M. Hutter

    (National Cancer Institute, National Institutes of Health)

  • Aaron K. Aragaki

    (Fred Hutchinson Cancer Research Center)

  • Katja Butterbach

    (German Cancer Research Center (DKFZ))

  • Bette J. Caan

    (Kaiser Permanente Medical Care Program of Northern California)

  • Christopher S. Carlson

    (Fred Hutchinson Cancer Research Center)

  • Stephen J. Chanock

    (National Cancer Institute)

  • Keith R. Curtis

    (Fred Hutchinson Cancer Research Center)

  • Charles S. Fuchs

    (Brigham and Women’s Hospital
    Dana-Farber Cancer Institute)

  • Manish Gala

    (Massachusetts General Hospital)

  • Edward L. Giovannucci

    (Harvard Medical School
    Brigham and Women’s Hospital)

  • Stephanie M. Gogarten

    (University of Washington)

  • Richard B. Hayes

    (New York University School of Medicine)

  • Brian Henderson

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • David J. Hunter

    (Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health)

  • Rebecca D. Jackson

    (Ohio State University)

  • Laurence N. Kolonel

    (Office of Public Health Studies, University of Hawaii Manoa)

  • Charles Kooperberg

    (Fred Hutchinson Cancer Research Center)

  • Sébastien Küry

    (Service de Génétique Médicale, CHU Nantes)

  • Andrea LaCroix

    (Fred Hutchinson Cancer Research Center)

  • Cathy C. Laurie

    (University of Washington)

  • Cecelia A. Laurie

    (University of Washington)

  • Mathieu Lemire

    (Ontario Institute for Cancer Research)

  • David Levine

    (University of Washington)

  • Jing Ma

    (Harvard School of Public Health)

  • Karen W. Makar

    (Fred Hutchinson Cancer Research Center)

  • Conghui Qu

    (Fred Hutchinson Cancer Research Center)

  • Darin Taverna

    (Phoenix College)

  • Cornelia M. Ulrich

    (Fred Hutchinson Cancer Research Center
    German Cancer Research Center
    University of Washington School of Public Health)

  • Kana Wu

    (Harvard School of Public Health)

  • Suminori Kono

    (Kyushu University)

  • Dee W. West

    (Cancer Registry of Greater California, Public Health Institute)

  • Sonja I. Berndt

    (National Cancer Institute)

  • Stéphane Bezieau

    (Centre Hospitalier Universitaire Hotel-Dieu)

  • Hermann Brenner

    (German Cancer Research Center (DKFZ))

  • Peter T. Campbell

    (Epidemiology Research Program, American Cancer Society)

  • Andrew T. Chan

    (Massachusetts General Hospital
    Harvard Medical School)

  • Jenny Chang-Claude

    (Unit of Genetic Epidemiology, German Cancer Research Center (DKFZ))

  • Gerhard A. Coetzee

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • David V. Conti

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
    Keck School of Medicine, University of Southern California)

  • David Duggan

    (Translational Genomics Research Institute)

  • Jane C. Figueiredo

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Barbara K. Fortini

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Steven J. Gallinger

    (Zane Cohen Centre for Digestive Diseases, Mount Sinai Hospital)

  • W. James Gauderman

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Graham Giles

    (Cancer Epidemiology Centre, Cancer Council Victoria)

  • Roger Green

    (Discipline of Genetics, Memorial University of Newfoundland)

  • Robert Haile

    (Stanford University)

  • Tabitha A. Harrison

    (Fred Hutchinson Cancer Research Center)

  • Michael Hoffmeister

    (German Cancer Research Center (DKFZ))

  • John L. Hopper

    (Centre for MEGA Epidemiology, The University of Melbourne)

  • Thomas J. Hudson

    (Ontario Institute for Cancer Research)

  • Eric Jacobs

    (Epidemiology Research Program, American Cancer Society)

  • Motoki Iwasaki

    (Research Center for Cancer Prevention and Screening, National Cancer Center)

  • Sun Ha Jee

    (Graduate School of Public Health, Yonsei University)

  • Mark Jenkins

    (Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne)

  • Wei-Hua Jia

    (State Key Laboratory of Oncology in South China, Cancer Center, Sun Yat-sen University)

  • Amit Joshi

    (Harvard School of Public Health)

  • Li Li

    (Case Western Reserve University)

  • Noralene M. Lindor

    (Mayo Clinic)

  • Keitaro Matsuo

    (Kyushu University)

  • Victor Moreno

    (Cancer Epidemiology Service, Catalan Institute of Oncology, IDIBELL)

  • Bhramar Mukherjee

    (University of Michigan)

  • Polly A. Newcomb

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center)

  • John D. Potter

    (Cancer Prevention Program, Fred Hutchinson Cancer Research Center)

  • Leon Raskin

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
    Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine
    Vanderbilt-Ingram Cancer Center, Vanderbilt University)

  • Gad Rennert

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
    Carmel Medical Center
    Clalit Health Services National Cancer Control Center
    Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology)

  • Stephanie Rosse

    (Fred Hutchinson Cancer Research Center)

  • Gianluca Severi

    (Cancer Epidemiology Centre, Cancer Council Victoria
    Human Genetics Foundation (HuGeF))

  • Robert E. Schoen

    (University of Pittsburgh Medical Center)

  • Daniela Seminara

    (Epidemiology and Genomics Research Program, National Cancer Institute, National Institutes of Health)

  • Xiao-Ou Shu

    (Vanderbilt-Ingram Cancer Center, Vanderbilt University
    Vanderbilt University School of Medicine)

  • Martha L. Slattery

    (University of Utah Health Sciences Center)

  • Shoichiro Tsugane

    (Research Center for Cancer Prevention and Screening, National Cancer Center)

  • Emily White

    (Fred Hutchinson Cancer Research Center)

  • Yong-Bing Xiang

    (Shanghai Cancer Institute)

  • Brent W. Zanke

    (The University of Ottawa
    Clinical Epidemiology Program, Ottawa Hospital Research Institute)

  • Wei Zheng

    (Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine
    Vanderbilt-Ingram Cancer Center, Vanderbilt University)

  • Loic Le Marchand

    (Epidemiology Program, University of Hawaii Cancer Center)

  • Graham Casey

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California)

  • Stephen B. Gruber

    (USC Norris Comprehensive Cancer Center, Keck School of Medicine, University of Southern California
    Keck School of Medicine, University of Southern California)

  • Ulrike Peters

    (Fred Hutchinson Cancer Research Center)

Abstract

Genetic susceptibility to colorectal cancer is caused by rare pathogenic mutations and common genetic variants that contribute to familial risk. Here we report the results of a two-stage association study with 18,299 cases of colorectal cancer and 19,656 controls, with follow-up of the most statistically significant genetic loci in 4,725 cases and 9,969 controls from two Asian consortia. We describe six new susceptibility loci reaching a genome-wide threshold of P

Suggested Citation

  • Fredrick R. Schumacher & Stephanie L. Schmit & Shuo Jiao & Christopher K. Edlund & Hansong Wang & Ben Zhang & Li Hsu & Shu-Chen Huang & Christopher P. Fischer & John F. Harju & Gregory E. Idos & Flavi, 2015. "Genome-wide association study of colorectal cancer identifies six new susceptibility loci," Nature Communications, Nature, vol. 6(1), pages 1-7, November.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8138
    DOI: 10.1038/ncomms8138
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms8138
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms8138?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Pingting Ying & Can Chen & Zequn Lu & Shuoni Chen & Ming Zhang & Yimin Cai & Fuwei Zhang & Jinyu Huang & Linyun Fan & Caibo Ning & Yanmin Li & Wenzhuo Wang & Hui Geng & Yizhuo Liu & Wen Tian & Zhiyong, 2023. "Genome-wide enhancer-gene regulatory maps link causal variants to target genes underlying human cancer risk," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    2. Rikifumi Ohta & Yosuke Tanigawa & Yuta Suzuki & Manolis Kellis & Shinichi Morishita, 2024. "A polygenic score method boosted by non-additive models," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms8138. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.