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Asymmetrically dividing Drosophila neuroblasts utilize two spatially and temporally independent cytokinesis pathways

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  • Michaela Roth

    (Biozentrum, University of Basel
    Present address: Department of Clinical Science, Translational Neurology, Lund University, Wallenberg Neuroscience Center, Lund 22184, Sweden)

  • Chantal Roubinet

    (Biozentrum, University of Basel)

  • Niklas Iffländer

    (Biozentrum, University of Basel)

  • Alexia Ferrand

    (Biozentrum, University of Basel
    Imaging Core Facility (IMCF), Biozentrum, University of Basel)

  • Clemens Cabernard

    (Biozentrum, University of Basel)

Abstract

Precise cleavage furrow positioning is required for faithful chromosome segregation and cell fate determinant distribution. In most metazoan cells, contractile ring placement is regulated by the mitotic spindle through the centralspindlin complex, and potentially also the chromosomal passenger complex (CPC). Drosophila neuroblasts, asymmetrically dividing neural stem cells, but also other cells utilize both spindle-dependent and spindle-independent cleavage furrow positioning pathways. However, the relative contribution of each pathway towards cytokinesis is currently unclear. Here we report that in Drosophila neuroblasts, the mitotic spindle, but not polarity cues, controls the localization of the CPC component Survivin. We also show that Survivin and the mitotic spindle are required to stabilize the position of the cleavage furrow in late anaphase and to complete furrow constriction. These results support the model that two spatially and temporally separate pathways control different key aspects during asymmetric cell division, ensuring correct cell fate determinant segregation and neuroblast self-renewal.

Suggested Citation

  • Michaela Roth & Chantal Roubinet & Niklas Iffländer & Alexia Ferrand & Clemens Cabernard, 2015. "Asymmetrically dividing Drosophila neuroblasts utilize two spatially and temporally independent cytokinesis pathways," Nature Communications, Nature, vol. 6(1), pages 1-14, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7551
    DOI: 10.1038/ncomms7551
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    Cited by:

    1. Emilie Montembault & Irène Deduyer & Marie-Charlotte Claverie & Lou Bouit & Nicolas J. Tourasse & Denis Dupuy & Derek McCusker & Anne Royou, 2023. "Two RhoGEF isoforms with distinct localisation control furrow position during asymmetric cell division," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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