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Gut microbiome development along the colorectal adenoma–carcinoma sequence

Author

Listed:
  • Qiang Feng

    (BGI-Shenzhen
    University of Copenhagen)

  • Suisha Liang

    (BGI-Shenzhen
    School of Bioscience and Biotechnology, South China University of Technology)

  • Huijue Jia

    (BGI-Shenzhen)

  • Andreas Stadlmayr

    (Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg)

  • Longqing Tang

    (BGI-Shenzhen)

  • Zhou Lan

    (BGI-Shenzhen)

  • Dongya Zhang

    (BGI-Shenzhen)

  • Huihua Xia

    (BGI-Shenzhen)

  • Xiaoying Xu

    (BGI-Shenzhen)

  • Zhuye Jie

    (BGI-Shenzhen)

  • Lili Su

    (BGI-Shenzhen)

  • Xiaoping Li

    (BGI-Shenzhen)

  • Xin Li

    (BGI-Shenzhen)

  • Junhua Li

    (BGI-Shenzhen
    School of Bioscience and Biotechnology, South China University of Technology
    BGI Hong Kong Research Institute)

  • Liang Xiao

    (BGI-Shenzhen)

  • Ursula Huber-Schönauer

    (Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg)

  • David Niederseer

    (Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg)

  • Xun Xu

    (BGI-Shenzhen)

  • Jumana Yousuf Al-Aama

    (BGI-Shenzhen
    Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University)

  • Huanming Yang

    (BGI-Shenzhen)

  • Jian Wang

    (BGI-Shenzhen)

  • Karsten Kristiansen

    (BGI-Shenzhen
    University of Copenhagen)

  • Manimozhiyan Arumugam

    (BGI-Shenzhen
    The Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen)

  • Herbert Tilg

    (Medical University Innsbruck)

  • Christian Datz

    (Hospital Oberndorf, Teaching Hospital of the Paracelsus Private University of Salzburg)

  • Jun Wang

    (BGI-Shenzhen
    University of Copenhagen
    Princess Al Jawhara Center of Excellence in the Research of Hereditary Disorders, King Abdulaziz University
    Macau University of Science and Technology, Avenida Wai long)

Abstract

Colorectal cancer, a commonly diagnosed cancer in the elderly, often develops slowly from benign polyps called adenoma. The gut microbiota is believed to be directly involved in colorectal carcinogenesis. The identity and functional capacity of the adenoma- or carcinoma-related gut microbe(s), however, have not been surveyed in a comprehensive manner. Here we perform a metagenome-wide association study (MGWAS) on stools from advanced adenoma and carcinoma patients and from healthy subjects, revealing microbial genes, strains and functions enriched in each group. An analysis of potential risk factors indicates that high intake of red meat relative to fruits and vegetables appears to associate with outgrowth of bacteria that might contribute to a more hostile gut environment. These findings suggest that faecal microbiome-based strategies may be useful for early diagnosis and treatment of colorectal adenoma or carcinoma.

Suggested Citation

  • Qiang Feng & Suisha Liang & Huijue Jia & Andreas Stadlmayr & Longqing Tang & Zhou Lan & Dongya Zhang & Huihua Xia & Xiaoying Xu & Zhuye Jie & Lili Su & Xiaoping Li & Xin Li & Junhua Li & Liang Xiao & , 2015. "Gut microbiome development along the colorectal adenoma–carcinoma sequence," Nature Communications, Nature, vol. 6(1), pages 1-13, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7528
    DOI: 10.1038/ncomms7528
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    Cited by:

    1. Lulu Sun & Yi Zhang & Jie Cai & Bipin Rimal & Edson R. Rocha & James P. Coleman & Chenran Zhang & Robert G. Nichols & Yuhong Luo & Bora Kim & Yaozong Chen & Kristopher W. Krausz & Curtis C. Harris & A, 2023. "Bile salt hydrolase in non-enterotoxigenic Bacteroides potentiates colorectal cancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Qi Su & Qin Liu & Raphaela Iris Lau & Jingwan Zhang & Zhilu Xu & Yun Kit Yeoh & Thomas W. H. Leung & Whitney Tang & Lin Zhang & Jessie Q. Y. Liang & Yuk Kam Yau & Jiaying Zheng & Chengyu Liu & Mengjin, 2022. "Faecal microbiome-based machine learning for multi-class disease diagnosis," Nature Communications, Nature, vol. 13(1), pages 1-8, December.
    3. Efrat Muller & Itamar Shiryan & Elhanan Borenstein, 2024. "Multi-omic integration of microbiome data for identifying disease-associated modules," Nature Communications, Nature, vol. 15(1), pages 1-13, December.
    4. Liyun An & Xinwu Liu & Jianwei Wang & Jinbo Xu & Xiaoli Chen & Xiaonan Liu & Bingxin Hu & Yong Nie & Xiao-Lei Wu, 2024. "Global diversity and ecological functions of viruses inhabiting oil reservoirs," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    5. Wanting Dong & Xinyue Fan & Yaqiong Guo & Siyi Wang & Shulei Jia & Na Lv & Tao Yuan & Yuanlong Pan & Yong Xue & Xi Chen & Qian Xiong & Ruifu Yang & Weigang Zhao & Baoli Zhu, 2024. "An expanded database and analytical toolkit for identifying bacterial virulence factors and their associations with chronic diseases," Nature Communications, Nature, vol. 15(1), pages 1-16, December.
    6. Youwen Qin & Xin Tong & Wei-Jian Mei & Yanshuang Cheng & Yuanqiang Zou & Kai Han & Jiehai Yu & Zhuye Jie & Tao Zhang & Shida Zhu & Xin Jin & Jian Wang & Huanming Yang & Xun Xu & Huanzi Zhong & Liang X, 2024. "Consistent signatures in the human gut microbiome of old- and young-onset colorectal cancer," Nature Communications, Nature, vol. 15(1), pages 1-13, December.

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