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Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4

Author

Listed:
  • Simon B. Saucet

    (Sainsbury Laboratory, Norwich Research Park)

  • Yan Ma

    (Sainsbury Laboratory, Norwich Research Park)

  • Panagiotis F. Sarris

    (Sainsbury Laboratory, Norwich Research Park)

  • Oliver J. Furzer

    (Sainsbury Laboratory, Norwich Research Park)

  • Kee Hoon Sohn

    (Bioprotection Research Centre, Institute of Agriculture and Environment, Massey University)

  • Jonathan D.G. Jones

    (Sainsbury Laboratory, Norwich Research Park)

Abstract

Plant immunity requires recognition of pathogen effectors by intracellular NB-LRR immune receptors encoded by Resistance (R) genes. Most R proteins recognize a specific effector, but some function in pairs that recognize multiple effectors. Arabidopsis thaliana TIR-NB-LRR proteins RRS1-R and RPS4 together recognize two bacterial effectors, AvrRps4 from Pseudomonas syringae and PopP2 from Ralstonia solanacearum. However, AvrRps4, but not PopP2, is recognized in rrs1/rps4 mutants. We reveal an R gene pair that resembles and is linked to RRS1/RPS4, designated as RRS1B/RPS4B, which confers recognition of AvrRps4 but not PopP2. Like RRS1/RPS4, RRS1B/RPS4B proteins associate and activate defence genes upon AvrRps4 recognition. Inappropriate combinations (RRS1/RPS4B or RRS1B/RPS4) are non-functional and this specificity is not TIR domain dependent. Distinct putative orthologues of both pairs are maintained in the genomes of Arabidopsis thaliana relatives and are likely derived from a common ancestor pair. Our results provide novel insights into paired R gene function and evolution.

Suggested Citation

  • Simon B. Saucet & Yan Ma & Panagiotis F. Sarris & Oliver J. Furzer & Kee Hoon Sohn & Jonathan D.G. Jones, 2015. "Two linked pairs of Arabidopsis TNL resistance genes independently confer recognition of bacterial effector AvrRps4," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7338
    DOI: 10.1038/ncomms7338
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    1. Arsheed H. Sheikh & Iosif Zacharia & Alonso J. Pardal & Ana Dominguez-Ferreras & Daniela J. Sueldo & Jung-Gun Kim & Alexi Balmuth & Jose R. Gutierrez & Brendon F. Conlan & Najeeb Ullah & Olivia M. Nip, 2023. "Dynamic changes of the Prf/Pto tomato resistance complex following effector recognition," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. Deepak D. Bhandari & Dae Kwan Ko & Sang-Jin Kim & Kinya Nomura & Sheng Yang He & Federica Brandizzi, 2023. "Defense against phytopathogens relies on efficient antimicrobial protein secretion mediated by the microtubule-binding protein TGNap1," Nature Communications, Nature, vol. 14(1), pages 1-16, December.
    3. Yuying Li & Qiong Wang & Huimin Jia & Kazuya Ishikawa & Ken-ichi Kosami & Takahiro Ueba & Atsumi Tsujimoto & Miki Yamanaka & Yasuyuki Yabumoto & Daisuke Miki & Eriko Sasaki & Yoichiro Fukao & Masayuki, 2024. "An NLR paralog Pit2 generated from tandem duplication of Pit1 fine-tunes Pit1 localization and function," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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