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Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci

Author

Listed:
  • Mathieu Lemire

    (Ontario Institute for Cancer Research)

  • Syed H.E. Zaidi

    (Ontario Institute for Cancer Research)

  • Maria Ban

    (University of Cambridge)

  • Bing Ge

    (McGill University and Genome Québec Innovation Centre)

  • Dylan Aïssi

    (INSERM, UMR-S 1166
    Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics and Pathophysiology of Cardiovascular Diseases
    ICAN Institute for Cardiometabolism and Nutrition)

  • Marine Germain

    (INSERM, UMR-S 1166
    Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics and Pathophysiology of Cardiovascular Diseases
    ICAN Institute for Cardiometabolism and Nutrition)

  • Irfahan Kassam

    (Dalla Lana School of Public Health, University of Toronto)

  • Mike Wang

    (Ontario Institute for Cancer Research)

  • Brent W. Zanke

    (University of Ottawa, Ottawa Hospital Research Institute)

  • France Gagnon

    (Dalla Lana School of Public Health, University of Toronto)

  • Pierre-Emmanuel Morange

    (Laboratory of Haematology, La Timone Hospital
    INSERM, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis
    Aix-Marseille University, UMR_S 1062, Nutrition Obesity and Risk of Thrombosis)

  • David-Alexandre Trégouët

    (INSERM, UMR-S 1166
    Sorbonne Universités, UPMC Univ Paris 06, UMR_S 1166, Team Genomics and Pathophysiology of Cardiovascular Diseases
    ICAN Institute for Cardiometabolism and Nutrition)

  • Philip S. Wells

    (University of Ottawa, Ottawa Hospital Research Institute)

  • Stephen Sawcer

    (University of Cambridge)

  • Steven Gallinger

    (Samuel Lunenfeld Research Institute
    Toronto General Hospital)

  • Tomi Pastinen

    (McGill University and Genome Québec Innovation Centre)

  • Thomas J. Hudson

    (Ontario Institute for Cancer Research
    University of Toronto
    University of Toronto)

Abstract

The interplay between genetic and epigenetic variation is only partially understood. One form of epigenetic variation is methylation at CpG sites, which can be measured as methylation quantitative trait loci (meQTL). Here we report that in a panel of lymphocytes from 1,748 individuals, methylation levels at 1,919 CpG sites are correlated with at least one distal (trans) single-nucleotide polymorphism (SNP) (P 1 Mb apart. Over 90% of these pairs are replicated (FDR

Suggested Citation

  • Mathieu Lemire & Syed H.E. Zaidi & Maria Ban & Bing Ge & Dylan Aïssi & Marine Germain & Irfahan Kassam & Mike Wang & Brent W. Zanke & France Gagnon & Pierre-Emmanuel Morange & David-Alexandre Trégouët, 2015. "Long-range epigenetic regulation is conferred by genetic variation located at thousands of independent loci," Nature Communications, Nature, vol. 6(1), pages 1-12, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7326
    DOI: 10.1038/ncomms7326
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    Cited by:

    1. Jacob Bergstedt & Sadoune Ait Kaci Azzou & Kristin Tsuo & Anthony Jaquaniello & Alejandra Urrutia & Maxime Rotival & David T. S. Lin & Julia L. MacIsaac & Michael S. Kobor & Matthew L. Albert & Darrag, 2022. "The immune factors driving DNA methylation variation in human blood," Nature Communications, Nature, vol. 13(1), pages 1-20, December.
    2. Jayshree Advani & Puja A. Mehta & Andrew R. Hamel & Sudeep Mehrotra & Christina Kiel & Tobias Strunz & Ximena Corso-Díaz & Madeline Kwicklis & Freekje Asten & Rinki Ratnapriya & Emily Y. Chew & Dena G, 2024. "QTL mapping of human retina DNA methylation identifies 87 gene-epigenome interactions in age-related macular degeneration," Nature Communications, Nature, vol. 15(1), pages 1-20, December.

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