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The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion

Author

Listed:
  • Shangbang Gao

    (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital)

  • Lin Xie

    (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
    Institute of Medical Science, University of Toronto)

  • Taizo Kawano

    (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
    Present address: Graduate School of Science, Kobe University, Rokkodaicho, Nadaku, Kobe, Japan 657-8501)

  • Michelle D. Po

    (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
    University of Toronto)

  • Jennifer K. Pirri

    (University of Massachusetts Medical School, Worcester, Massachusetts, USA.)

  • Sihui Guan

    (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
    Institute of Medical Science, University of Toronto)

  • Mark J. Alkema

    (University of Massachusetts Medical School, Worcester, Massachusetts, USA.)

  • Mei Zhen

    (Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital
    Institute of Medical Science, University of Toronto
    University of Toronto
    University of Toronto, Toronto, Ontario, Canada M5S 1A8.)

Abstract

Persistent neural activity, a sustained circuit output that outlasts the stimuli, underlies short-term or working memory, as well as various mental representations. Molecular mechanisms that underlie persistent activity are not well understood. Combining in situ whole-cell patch clamping and quantitative locomotion analyses, we show here that the Caenorhabditis elegans neuromuscular system exhibits persistent rhythmic activity, and such an activity contributes to the sustainability of basal locomotion, and the maintenance of acceleration after stimulation. The NALCN family sodium leak channel regulates the resting membrane potential and excitability of invertebrate and vertebrate neurons. Our molecular genetics and electrophysiology analyses show that the C. elegans NALCN, NCA, activates a premotor interneuron network to potentiate persistent motor circuit activity and to sustain C. elegans locomotion. Collectively, these results reveal a mechanism for, and physiological function of, persistent neural activity using a simple animal model, providing potential mechanistic clues for working memory in other systems.

Suggested Citation

  • Shangbang Gao & Lin Xie & Taizo Kawano & Michelle D. Po & Jennifer K. Pirri & Sihui Guan & Mark J. Alkema & Mei Zhen, 2015. "The NCA sodium leak channel is required for persistent motor circuit activity that sustains locomotion," Nature Communications, Nature, vol. 6(1), pages 1-11, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7323
    DOI: 10.1038/ncomms7323
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    Cited by:

    1. Stanislav Nagy & Marc Goessling & Yali Amit & David Biron, 2015. "A Generative Statistical Algorithm for Automatic Detection of Complex Postures," PLOS Computational Biology, Public Library of Science, vol. 11(10), pages 1-23, October.

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