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Trans-mitochondrial coordination of cristae at regulated membrane junctions

Author

Listed:
  • Martin Picard

    (Center for Mitochondrial and Epigenomic Medicine, The Children’s Hospital of Philadelphia and University of Pennsylvania)

  • Meagan J. McManus

    (Center for Mitochondrial and Epigenomic Medicine, The Children’s Hospital of Philadelphia and University of Pennsylvania)

  • György Csordás

    (MitoCare Center, Anatomy and Cell Biology, Thomas Jefferson University)

  • Péter Várnai

    (Semmelweis University)

  • Gerald W. Dorn II

    (Center for Pharmacogenomics, Washington University School of Medicine)

  • Dewight Williams

    (Penn EM Resource Laboratory, University of Pennsylvania)

  • György Hajnóczky

    (MitoCare Center, Anatomy and Cell Biology, Thomas Jefferson University)

  • Douglas C. Wallace

    (Center for Mitochondrial and Epigenomic Medicine, The Children’s Hospital of Philadelphia and University of Pennsylvania)

Abstract

Reminiscent of bacterial quorum sensing, mammalian mitochondria participate in inter-organelle communication. However, physical structures that enhance or enable interactions between mitochondria have not been defined. Here we report that adjacent mitochondria exhibit coordination of inner mitochondrial membrane cristae at inter-mitochondrial junctions (IMJs). These electron-dense structures are conserved across species, resistant to genetic disruption of cristae organization, dynamically modulated by mitochondrial bioenergetics, independent of known inter-mitochondrial tethering proteins mitofusins and rapidly induced by the stable rapprochement of organelles via inducible synthetic linker technology. At the associated junctions, the cristae of adjacent mitochondria form parallel arrays perpendicular to the IMJ, consistent with a role in electrochemical coupling. These IMJs and associated cristae arrays may provide the structural basis to enhance the propagation of intracellular bioenergetic and apoptotic waves through mitochondrial networks within cells.

Suggested Citation

  • Martin Picard & Meagan J. McManus & György Csordás & Péter Várnai & Gerald W. Dorn II & Dewight Williams & György Hajnóczky & Douglas C. Wallace, 2015. "Trans-mitochondrial coordination of cristae at regulated membrane junctions," Nature Communications, Nature, vol. 6(1), pages 1-8, May.
  • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms7259
    DOI: 10.1038/ncomms7259
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    Cited by:

    1. William A. Hofstadter & Katelyn C. Cook & Elene Tsopurashvili & Robert Gebauer & Vojtěch Pražák & Emily A. Machala & Ji Woo Park & Kay Grünewald & Emmanuelle R. J. Quemin & Ileana M. Cristea, 2024. "Infection-induced peripheral mitochondria fission drives ER encapsulations and inter-mitochondria contacts that rescue bioenergetics," Nature Communications, Nature, vol. 15(1), pages 1-24, December.

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