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Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light

Author

Listed:
  • Yan Liu

    (Optical Imaging Laboratory, Washington University in St. Louis)

  • Puxiang Lai

    (Optical Imaging Laboratory, Washington University in St. Louis)

  • Cheng Ma

    (Optical Imaging Laboratory, Washington University in St. Louis)

  • Xiao Xu

    (Optical Imaging Laboratory, Washington University in St. Louis)

  • Alexander A. Grabar

    (Institute of Solid State Physics and Chemistry, Uzhgorod National University)

  • Lihong V. Wang

    (Optical Imaging Laboratory, Washington University in St. Louis)

Abstract

Focusing light deep inside living tissue has not been achieved despite its promise to play a central role in biomedical imaging, optical manipulation and therapy. To address this challenge, internal-guide-star-based wavefront engineering techniques—for example, time-reversed ultrasonically encoded (TRUE) optical focusing—were developed. The speeds of these techniques, however, were limited to no greater than 1 Hz, preventing them from in vivo applications. Here we improve the speed of optical focusing deep inside scattering media by two orders of magnitude, and focus diffuse light inside a dynamic scattering medium having a speckle correlation time as short as 5.6 ms, typical of living tissue. By imaging a target, we demonstrate the first focusing of diffuse light inside a dynamic scattering medium containing living tissue. Since the achieved focusing speed approaches the tissue decorrelation rate, this work is an important step towards in vivo deep tissue noninvasive optical imaging, optogenetics and photodynamic therapy.

Suggested Citation

  • Yan Liu & Puxiang Lai & Cheng Ma & Xiao Xu & Alexander A. Grabar & Lihong V. Wang, 2015. "Optical focusing deep inside dynamic scattering media with near-infrared time-reversed ultrasonically encoded (TRUE) light," Nature Communications, Nature, vol. 6(1), pages 1-9, May.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms6904
    DOI: 10.1038/ncomms6904
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    Cited by:

    1. Che-Yung Shen & Jingxi Li & Tianyi Gan & Yuhang Li & Mona Jarrahi & Aydogan Ozcan, 2024. "All-optical phase conjugation using diffractive wavefront processing," Nature Communications, Nature, vol. 15(1), pages 1-21, December.

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