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An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding

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  • Patrick Sweeney

    (State University of New York Upstate Medical University, 505 Irving Avenue, IHP#3609, Syracuse, New York 13210, USA)

  • Yunlei Yang

    (State University of New York Upstate Medical University, 505 Irving Avenue, IHP#3609, Syracuse, New York 13210, USA)

Abstract

Previous research has focused on feeding circuits residing in the hindbrain and midbrain that govern homeostatic or hedonic control of food intake. However, the feeding circuits controlling emotional or cognitive aspects of food intake are largely unknown. Here we use chemical genetics and optogenetic techniques to dissect appetite control circuits originating from ventral hippocampus (vHPC), a brain region implicated in emotion and cognition. We find that the vHPC projects functional glutamatergic synaptic inputs to the lateral septum (LS) and optogenetic activation of vHPC projections in LS reduces food intake. Consistently, food intake is suppressed by chemogenetic activation of glutamatergic neurons in the vHPC that project to the LS and inactivation of LS neurons blunts vHPC-induced suppression of feeding. Collectively, our results identify an anorexigenic neural circuit originating from vHPC to LS in the brain, revealing a potential therapeutic target for the treatment of anorexia or other appetite disorders.

Suggested Citation

  • Patrick Sweeney & Yunlei Yang, 2015. "An excitatory ventral hippocampus to lateral septum circuit that suppresses feeding," Nature Communications, Nature, vol. 6(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:6:y:2015:i:1:d:10.1038_ncomms10188
    DOI: 10.1038/ncomms10188
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    Cited by:

    1. Khairunisa Mohamad Ibrahim & Nicolas Massaly & Hye-Jean Yoon & Rossana Sandoval & Allie J. Widman & Robert J. Heuermann & Sidney Williams & William Post & Sulan Pathiranage & Tania Lintz & Azra Zec & , 2024. "Dorsal hippocampus to nucleus accumbens projections drive reinforcement via activation of accumbal dynorphin neurons," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Hao-Shan Chen & Xiao-Long Zhang & Rong-Rong Yang & Guang-Ling Wang & Xin-Yue Zhu & Yuan-Fang Xu & Dan-Yang Wang & Na Zhang & Shou Qiu & Li-Jie Zhan & Zhi-Ming Shen & Xiao-Hong Xu & Gang Long & Chun Xu, 2022. "An intein-split transactivator for intersectional neural imaging and optogenetic manipulation," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    3. Dylan C. M. Yeates & Dallas Leavitt & Sajeevan Sujanthan & Nisma Khan & Denada Alushaj & Andy C. H. Lee & Rutsuko Ito, 2022. "Parallel ventral hippocampus-lateral septum pathways differentially regulate approach-avoidance conflict," Nature Communications, Nature, vol. 13(1), pages 1-13, December.

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