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A dynamic supramolecular polymer with stimuli-responsive handedness for in situ probing of enzymatic ATP hydrolysis

Author

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  • Mohit Kumar

    (New Chemistry Unit, Supramolecular Chemistry Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR))

  • Patrick Brocorens

    (Laboratory for Chemistry of Novel Materials, Center for Innovation and Research in Materials and Polymers, University of Mons—UMONS)

  • Claire Tonnelé

    (Laboratory for Chemistry of Novel Materials, Center for Innovation and Research in Materials and Polymers, University of Mons—UMONS)

  • David Beljonne

    (Laboratory for Chemistry of Novel Materials, Center for Innovation and Research in Materials and Polymers, University of Mons—UMONS)

  • Mathieu Surin

    (Laboratory for Chemistry of Novel Materials, Center for Innovation and Research in Materials and Polymers, University of Mons—UMONS)

  • Subi J. George

    (New Chemistry Unit, Supramolecular Chemistry Laboratory, Jawaharlal Nehru Centre for Advanced Scientific Research (JNCASR))

Abstract

Design of artificial systems, which can respond to fluctuations in concentration of adenosine phosphates (APs), can be useful in understanding various biological processes. Helical assemblies of chromophores, which dynamically respond to such changes, can provide real-time chiroptical readout of various chemical transformations. Towards this concept, here we present a supramolecular helix of achiral chromophores, which shows chiral APs responsive tunable handedness along with dynamically switchable helicity. This system, composing of naphthalenediimides with phosphate recognition unit, shows opposite handedness on binding with ATP compared with ADP or AMP, which is comprehensively analysed with molecular dynamic simulations. Such differential signalling along with stimuli-dependent fast stereomutations have been capitalized to probe the reaction kinetics of enzymatic ATP hydrolysis. Detailed chiroptical analyses provide mechanistic insights into the enzymatic hydrolysis and various intermediate steps. Thus, a unique dynamic helical assembly to monitor the real-time reaction processes via its stimuli-responsive chiroptical signalling is conceptualized.

Suggested Citation

  • Mohit Kumar & Patrick Brocorens & Claire Tonnelé & David Beljonne & Mathieu Surin & Subi J. George, 2014. "A dynamic supramolecular polymer with stimuli-responsive handedness for in situ probing of enzymatic ATP hydrolysis," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6793
    DOI: 10.1038/ncomms6793
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    Cited by:

    1. Martina Crippa & Claudio Perego & Anna L. Marco & Giovanni M. Pavan, 2022. "Molecular communications in complex systems of dynamic supramolecular polymers," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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