IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms6659.html
   My bibliography  Save this article

The role of protein clearance mechanisms in organismal ageing and age-related diseases

Author

Listed:
  • David Vilchez

    (Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne)

  • Isabel Saez

    (Cologne Excellence Cluster for Cellular Stress Responses in Aging-Associated Diseases (CECAD), University of Cologne)

  • Andrew Dillin

    (The University of California, Berkeley, Li Ka Shing Center for Biomedical and Health Sciences
    Howard Hughes Medical Institute, The University of California)

Abstract

Proteins are subject to continuous and complex quality-control mechanisms, which ensure integrity of the proteome. Vilchez et al.review how a demise in these processes, collectively referred to as proteostasis, is linked to organismal ageing and the development of age-associated diseases.

Suggested Citation

  • David Vilchez & Isabel Saez & Andrew Dillin, 2014. "The role of protein clearance mechanisms in organismal ageing and age-related diseases," Nature Communications, Nature, vol. 5(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6659
    DOI: 10.1038/ncomms6659
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms6659
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms6659?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Hanxiao Zhang & Chenyu Zhou & Zarith Mohammad & Jianhua Zhao, 2024. "Structural basis of human 20S proteasome biogenesis," Nature Communications, Nature, vol. 15(1), pages 1-11, December.
    2. Alexander Popov & Nadezda Brazhe & Kseniia Morozova & Konstantin Yashin & Maxim Bychkov & Olga Nosova & Oksana Sutyagina & Alexey Brazhe & Evgenia Parshina & Li Li & Igor Medyanik & Dmitry E. Korzhevs, 2023. "Mitochondrial malfunction and atrophy of astrocytes in the aged human cerebral cortex," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6659. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.