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Unique features of the m6A methylome in Arabidopsis thaliana

Author

Listed:
  • Guan-Zheng Luo

    (The University of Chicago
    Howard Hughes Medical Institute, The University of Chicago)

  • Alice MacQueen

    (The University of Chicago)

  • Guanqun Zheng

    (The University of Chicago
    Howard Hughes Medical Institute, The University of Chicago)

  • Hongchao Duan

    (Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University)

  • Louis C. Dore

    (The University of Chicago
    Howard Hughes Medical Institute, The University of Chicago)

  • Zhike Lu

    (The University of Chicago
    Howard Hughes Medical Institute, The University of Chicago)

  • Jun Liu

    (Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University)

  • Kai Chen

    (The University of Chicago
    Howard Hughes Medical Institute, The University of Chicago)

  • Guifang Jia

    (Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University)

  • Joy Bergelson

    (The University of Chicago)

  • Chuan He

    (The University of Chicago
    Howard Hughes Medical Institute, The University of Chicago
    Synthetic and Functional Biomolecules Center, Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University)

Abstract

Recent discoveries of reversible N6-methyladenosine (m6A) methylation on messenger RNA (mRNA) and mapping of m6A methylomes in mammals and yeast have revealed potential regulatory functions of this RNA modification. In plants, defects in m6A methyltransferase cause an embryo-lethal phenotype, suggesting a critical role of m6A in plant development. Here, we profile m6A transcriptome-wide in two accessions of Arabidopsis thaliana and reveal that m6A is a highly conserved modification of mRNA in plants. Distinct from mammals, m6A in A. thaliana is enriched not only around the stop codon and within 3′-untranslated regions, but also around the start codon. Gene ontology analysis indicates that the unique distribution pattern of m6A in A. thaliana is associated with plant-specific pathways involving the chloroplast. We also discover a positive correlation between m6A deposition and mRNA abundance, suggesting a regulatory role of m6A in plant gene expression.

Suggested Citation

  • Guan-Zheng Luo & Alice MacQueen & Guanqun Zheng & Hongchao Duan & Louis C. Dore & Zhike Lu & Jun Liu & Kai Chen & Guifang Jia & Joy Bergelson & Chuan He, 2014. "Unique features of the m6A methylome in Arabidopsis thaliana," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6630
    DOI: 10.1038/ncomms6630
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    Cited by:

    1. Man Zhang & Yunping Zeng & Rong Peng & Jie Dong & Yelin Lan & Sujuan Duan & Zhenyi Chang & Jian Ren & Guanzheng Luo & Bing Liu & Kamil Růžička & Kewei Zhao & Hong-Bin Wang & Hong-Lei Jin, 2022. "N6-methyladenosine RNA modification regulates photosynthesis during photodamage in plants," Nature Communications, Nature, vol. 13(1), pages 1-19, December.
    2. Guanqun Wang & Haoxuan Li & Chang Ye & Kayla He & Shun Liu & Bochen Jiang & Ruiqi Ge & Boyang Gao & Jiangbo Wei & Yutao Zhao & Aixuan Li & Di Zhang & Jianhua Zhang & Chuan He, 2024. "Quantitative profiling of m6A at single base resolution across the life cycle of rice and Arabidopsis," Nature Communications, Nature, vol. 15(1), pages 1-14, December.

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