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FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling

Author

Listed:
  • Yoonsung Lee

    (University of California, San Diego)

  • Jennifer E. Manegold

    (University of California, San Diego)

  • Albert D. Kim

    (University of California, San Diego)

  • Claire Pouget

    (University of California, San Diego)

  • David L. Stachura

    (University of California, San Diego
    California State University)

  • Wilson K. Clements

    (University of California, San Diego
    St Jude Children’s Research Hospital)

  • David Traver

    (University of California, San Diego)

Abstract

Haematopoietic stem cells (HSCs) derive from haemogenic endothelial cells of the primitive dorsal aorta (DA) during vertebrate embryogenesis. The molecular mechanisms governing this unique endothelial to haematopoietic transition remain unclear. Here, we demonstrate a novel requirement for fibroblast growth factor (FGF) signalling in HSC emergence. This requirement is non-cell-autonomous, and acts within the somite to bridge the Wnt and Notch signalling pathways. We previously demonstrated that Wnt16 regulates the somitic expression of two Notch ligands, deltaC (dlc) and deltaD (dld), whose combined function is required for HSC fate. How Wnt16 connects to Notch function has remained an open question. Our current studies demonstrate that FGF signalling, via FGF receptor 4 (Fgfr4), mediates a signal-transduction pathway between Wnt16 and Dlc, but not Dld, to regulate HSC specification. Our findings demonstrate that FGF signalling acts as a key molecular relay within the developmental HSC niche to instruct HSC fate.

Suggested Citation

  • Yoonsung Lee & Jennifer E. Manegold & Albert D. Kim & Claire Pouget & David L. Stachura & Wilson K. Clements & David Traver, 2014. "FGF signalling specifies haematopoietic stem cells through its regulation of somitic Notch signalling," Nature Communications, Nature, vol. 5(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6583
    DOI: 10.1038/ncomms6583
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    Cited by:

    1. Clyde A. Campbell & Rodolfo Calderon & Giulia Pavani & Xiaoyi Cheng & Radwa Barakat & Elizabeth Snella & Fang Liu & Xiyu Peng & Jeffrey J. Essner & Karin S. Dorman & Maura McGrail & Paul Gadue & Debor, 2024. "p65 signaling dynamics drive the developmental progression of hematopoietic stem and progenitor cells through cell cycle regulation," Nature Communications, Nature, vol. 15(1), pages 1-22, December.

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