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The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer

Author

Listed:
  • Dimple Chakravarty

    (Weill Medical College of Cornell University
    Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital)

  • Andrea Sboner

    (Weill Medical College of Cornell University
    Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital
    Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University)

  • Sujit S. Nair

    (School of Medicine and Health Sciences, George Washington University)

  • Eugenia Giannopoulou

    (New York City College of Technology, City University of New York
    Arthritis and Tissue Degeneration Program and the David Z. Rosensweig Genomics Research Center, Hospital for Special Surgery)

  • Ruohan Li

    (School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia)

  • Sven Hennig

    (Chemical Genomics Centre)

  • Juan Miguel Mosquera

    (Weill Medical College of Cornell University
    Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital)

  • Jonathan Pauwels

    (Weill Medical College of Cornell University)

  • Kyung Park

    (Weill Medical College of Cornell University)

  • Myriam Kossai

    (Weill Medical College of Cornell University
    Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital)

  • Theresa Y. MacDonald

    (Weill Medical College of Cornell University)

  • Jacqueline Fontugne

    (Weill Medical College of Cornell University
    Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital)

  • Nicholas Erho

    (Research and Development, GenomeDx Biosciences)

  • Ismael A. Vergara

    (Research and Development, GenomeDx Biosciences)

  • Mercedeh Ghadessi

    (Research and Development, GenomeDx Biosciences)

  • Elai Davicioni

    (Research and Development, GenomeDx Biosciences)

  • Robert B. Jenkins

    (Mayo Clinic)

  • Nallasivam Palanisamy

    (Michigan Center for Translational Pathology, University of Michigan
    Henry Ford Health System, Medical Group Urology - Prostate Cancer Research, 1 Ford Place, Room 2D26)

  • Zhengming Chen

    (Weill Cornell Medical College)

  • Shinichi Nakagawa

    (RNA Biology Laboratory, RIKEN Advanced Research Institute)

  • Tetsuro Hirose

    (Institute for Genetic Medicine, Hokkaido University)

  • Neil H. Bander

    (Weill Cornell Medical College of Cornell University)

  • Himisha Beltran

    (Weill Medical College of Cornell University
    Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital)

  • Archa H. Fox

    (School of Biomedical, Biomolecular and Chemical Sciences, University of Western Australia)

  • Olivier Elemento

    (Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital
    Institute for Computational Biomedicine, Weill Cornell Medical College of Cornell University)

  • Mark A. Rubin

    (Weill Medical College of Cornell University
    Institute for Precision Medicine, Weill Medical College of Cornell University and New York Presbyterian Hospital)

Abstract

The androgen receptor (AR) plays a central role in establishing an oncogenic cascade that drives prostate cancer progression. Some prostate cancers escape androgen dependence and are often associated with an aggressive phenotype. The oestrogen receptor alpha (ERα) is expressed in prostate cancers, independent of AR status. However, the role of ERα remains elusive. Using a combination of chromatin immunoprecipitation (ChIP) and RNA-sequencing data, we identified an ERα-specific non-coding transcriptome signature. Among putatively ERα-regulated intergenic long non-coding RNAs (lncRNAs), we identified nuclear enriched abundant transcript 1 (NEAT1) as the most significantly overexpressed lncRNA in prostate cancer. Analysis of two large clinical cohorts also revealed that NEAT1 expression is associated with prostate cancer progression. Prostate cancer cells expressing high levels of NEAT1 were recalcitrant to androgen or AR antagonists. Finally, we provide evidence that NEAT1 drives oncogenic growth by altering the epigenetic landscape of target gene promoters to favour transcription.

Suggested Citation

  • Dimple Chakravarty & Andrea Sboner & Sujit S. Nair & Eugenia Giannopoulou & Ruohan Li & Sven Hennig & Juan Miguel Mosquera & Jonathan Pauwels & Kyung Park & Myriam Kossai & Theresa Y. MacDonald & Jacq, 2014. "The oestrogen receptor alpha-regulated lncRNA NEAT1 is a critical modulator of prostate cancer," Nature Communications, Nature, vol. 5(1), pages 1-16, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6383
    DOI: 10.1038/ncomms6383
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    Cited by:

    1. Claudia Fierro & Veronica Gatti & Veronica Banca & Sara Domenico & Stefano Scalera & Giacomo Corleone & Maurizio Fanciulli & Francesca Nicola & Alessandro Mauriello & Manuela Montanaro & George A. Cal, 2023. "The long non-coding RNA NEAT1 is a ΔNp63 target gene modulating epidermal differentiation," Nature Communications, Nature, vol. 14(1), pages 1-15, December.

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