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Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2

Author

Listed:
  • K. Kai McKinstry

    (University of Massachusetts Medical School)

  • Tara M. Strutt

    (University of Massachusetts Medical School)

  • Bianca Bautista

    (University of Massachusetts Medical School)

  • Wenliang Zhang

    (University of Massachusetts Medical School)

  • Yi Kuang

    (University of Massachusetts Medical School)

  • Andrea M. Cooper

    (Trudeau Institute)

  • Susan L. Swain

    (University of Massachusetts Medical School)

Abstract

It is unclear how CD4 T-cell memory formation is regulated following pathogen challenge, and when critical mechanisms act to determine effector T-cell fate. Here, we report that following influenza infection most effectors require signals from major histocompatibility complex class II molecules and CD70 during a late window well after initial priming to become memory. During this timeframe, effector cells must produce IL-2 or be exposed to high levels of paracrine or exogenously added IL-2 to survive an otherwise rapid default contraction phase. Late IL-2 promotes survival through acute downregulation of apoptotic pathways in effector T cells and by permanently upregulating their IL-7 receptor expression, enabling IL-7 to sustain them as memory T cells. This new paradigm defines a late checkpoint during the effector phase at which cognate interactions direct CD4 T-cell memory generation.

Suggested Citation

  • K. Kai McKinstry & Tara M. Strutt & Bianca Bautista & Wenliang Zhang & Yi Kuang & Andrea M. Cooper & Susan L. Swain, 2014. "Effector CD4 T-cell transition to memory requires late cognate interactions that induce autocrine IL-2," Nature Communications, Nature, vol. 5(1), pages 1-12, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6377
    DOI: 10.1038/ncomms6377
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    Cited by:

    1. Dingxi Zhou & Mariana Borsa & Daniel J. Puleston & Susanne Zellner & Jesusa Capera & Sharon Sanderson & Martina Schifferer & Svenja S. Hester & Xin Ge & Roman Fischer & Luke Jostins & Christian Behren, 2022. "Mapping autophagosome contents identifies interleukin-7 receptor-α as a key cargo modulating CD4+ T cell proliferation," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Anja W. Olsen & Ida Rosenkrands & Christina S. Jacobsen & Hannah M. Cheeseman & Max P. Kristiansen & Jes Dietrich & Robin J. Shattock & Frank Follmann, 2024. "Immune signature of Chlamydia vaccine CTH522/CAF®01 translates from mouse-to-human and induces durable protection in mice," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    3. Katharina Wild & Maike Smits & Saskia Killmer & Shirin Strohmeier & Christoph Neumann-Haefelin & Bertram Bengsch & Florian Krammer & Martin Schwemmle & Maike Hofmann & Robert Thimme & Katharina Zoldan, 2021. "Pre-existing immunity and vaccine history determine hemagglutinin-specific CD4 T cell and IgG response following seasonal influenza vaccination," Nature Communications, Nature, vol. 12(1), pages 1-15, December.

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