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On the unfounded enthusiasm for soft selective sweeps

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  • Jeffrey D Jensen

    (School of Life Sciences, Ecole Polytechnique Fédérale de Lausanne (EPFL)
    Swiss Institute of Bioinformatics (SIB))

Abstract

Patterns of genomic variation can be used to identify targets of positive selection but understanding their mode of evolution is challenging. This review discusses theory and empirical evidence regarding soft sweep models and concludes that the recent enthusiasm for soft sweeps is unfounded.

Suggested Citation

  • Jeffrey D Jensen, 2014. "On the unfounded enthusiasm for soft selective sweeps," Nature Communications, Nature, vol. 5(1), pages 1-10, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6281
    DOI: 10.1038/ncomms6281
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    Cited by:

    1. Yichen Zheng & Thomas Wiehe, 2019. "Adaptation in structured populations and fuzzy boundaries between hard and soft sweeps," PLOS Computational Biology, Public Library of Science, vol. 15(11), pages 1-32, November.
    2. Parul Johri & Wolfgang Stephan & Jeffrey D Jensen, 2022. "Soft selective sweeps: Addressing new definitions, evaluating competing models, and interpreting empirical outliers," PLOS Genetics, Public Library of Science, vol. 18(2), pages 1-12, February.
    3. Garud, Nandita R. & Rosenberg, Noah A., 2015. "Enhancing the mathematical properties of new haplotype homozygosity statistics for the detection of selective sweeps," Theoretical Population Biology, Elsevier, vol. 102(C), pages 94-101.

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