Author
Listed:
- Jun Li
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University)
- Changming Li
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
East Hospital, Tongji University)
- Dasheng Zhang
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University)
- Dan Shi
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University)
- Man Qi
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
East Hospital, Tongji University)
- Jing Feng
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
East Hospital, Tongji University)
- Tianyou Yuan
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University)
- Xinran Xu
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University)
- Dandan Liang
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University)
- Liang Xu
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University)
- Hong Zhang
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University)
- Yi Liu
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University)
- Jinjin Chen
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
East Hospital, Tongji University)
- Jiangchuan Ye
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
East Hospital, Tongji University)
- Weifang Jiang
(Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)
- Yingyu Cui
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Tongji University School of Medicine)
- Yangyang Zhang
(the First Affiliated Hospital of Nanjing Medical University)
- Luying Peng
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University
Tongji University School of Medicine)
- Zhaonian Zhou
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Laboratory of Hypoxic Cardiovascular Physiology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences)
- Yi-Han Chen
(Key Laboratory of Arrhythmias of the Ministry of Education of China, East Hospital, Tongji University School of Medicine
Institute of Medical Genetics, Tongji University
East Hospital, Tongji University
Tongji University School of Medicine)
Abstract
Heart failure (HF) is associated with complicated molecular remodelling within cardiomyocytes; however, the mechanisms underlying this process remain unclear. Here we show that sorting nexin-13 (SNX13), a member of both the sorting nexin and the regulator of G protein signalling (RGS) protein families, is a potent mediator of HF. Decreased levels of SNX13 are observed in failing hearts of humans and of experimental animals. SNX13-deficient zebrafish recapitulate HF with striking cardiomyocyte apoptosis. Mechanistically, a reduction in SNX13 expression facilitates the degradative sorting of apoptosis repressor with caspase recruitment domain (ARC), which is a multifunctional inhibitor of apoptosis. Consequently, the apoptotic pathway is activated, resulting in the loss of cardiac cells and the dampening of cardiac function. The N-terminal PXA structure of SNX13 is responsible for mediating the endosomal trafficking of ARC. Thus, this study reveals that SNX13 profoundly affects cardiac performance through the SNX13-PXA-ARC-caspase signalling pathway.
Suggested Citation
Jun Li & Changming Li & Dasheng Zhang & Dan Shi & Man Qi & Jing Feng & Tianyou Yuan & Xinran Xu & Dandan Liang & Liang Xu & Hong Zhang & Yi Liu & Jinjin Chen & Jiangchuan Ye & Weifang Jiang & Yingyu C, 2014.
"SNX13 reduction mediates heart failure through degradative sorting of apoptosis repressor with caspase recruitment domain,"
Nature Communications, Nature, vol. 5(1), pages 1-13, December.
Handle:
RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6177
DOI: 10.1038/ncomms6177
Download full text from publisher
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms6177. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.