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Bone remodelling in humans is load-driven but not lazy

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  • Patrik Christen

    (Orthopaedic Biomechanics, Eindhoven University of Technology
    Present address: Institute for Biomechanics, ETH Zurich, Hönggerbergring 64, 8093 Zurich, Switzerland)

  • Keita Ito

    (Orthopaedic Biomechanics, Eindhoven University of Technology)

  • Rafaa Ellouz

    (INSERM UMR 1033, Hôpital Edouard Herriot, Université de Lyon)

  • Stephanie Boutroy

    (INSERM UMR 1033, Hôpital Edouard Herriot, Université de Lyon)

  • Elisabeth Sornay-Rendu

    (INSERM UMR 1033, Hôpital Edouard Herriot, Université de Lyon)

  • Roland D. Chapurlat

    (INSERM UMR 1033, Hôpital Edouard Herriot, Université de Lyon)

  • Bert van Rietbergen

    (Orthopaedic Biomechanics, Eindhoven University of Technology)

Abstract

During bone remodelling, bone cells are thought to add and remove tissue at sites with high and low loading, respectively. To predict remodelling, it was proposed that bone is removed below and added above certain thresholds of tissue loading and within these thresholds, called a ‘lazy zone’, no net change in bone mass occurs. Animal experiments linking mechanical loading with changes in bone density or microstructure support load-adaptive bone remodelling, while in humans the evidence for this relationship at the micro-scale is still lacking. Using new high-resolution CT imaging techniques and computational methods, we quantify microstructural changes and physiological tissue loading in humans. Here, we show that bone remodelling sites in healthy postmenopausal women strongly correlate with tissue loading following a linear relationship without a ‘lazy zone’ providing unbiased evidence for load-driven remodelling in humans. This suggests that human and animal bones both react to loading induced remodelling in a similar fashion.

Suggested Citation

  • Patrik Christen & Keita Ito & Rafaa Ellouz & Stephanie Boutroy & Elisabeth Sornay-Rendu & Roland D. Chapurlat & Bert van Rietbergen, 2014. "Bone remodelling in humans is load-driven but not lazy," Nature Communications, Nature, vol. 5(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5855
    DOI: 10.1038/ncomms5855
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    Cited by:

    1. Ying Yang & Pekka Paivinen & Chang Xie & Alexis Leigh Krup & Tomi P. Makela & Keith E. Mostov & Jeremy F. Reiter, 2021. "Ciliary Hedgehog signaling patterns the digestive system to generate mechanical forces driving elongation," Nature Communications, Nature, vol. 12(1), pages 1-14, December.
    2. Jorge Ayarza & Jun Wang & Hojin Kim & Pin-Ruei Huang & Britteny Cassaidy & Gangbin Yan & Chong Liu & Heinrich M. Jaeger & Stuart J. Rowan & Aaron P. Esser-Kahn, 2023. "Bioinspired mechanical mineralization of organogels," Nature Communications, Nature, vol. 14(1), pages 1-7, December.
    3. Safonov, Alexander & Adamatzky, Andrew, 2018. "Computing via material topology optimisation," Applied Mathematics and Computation, Elsevier, vol. 318(C), pages 109-120.

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