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Scalable high-density peptide arrays for comprehensive health monitoring

Author

Listed:
  • Joseph Barten Legutki

    (Center for Innovations in Medicine, Biodesign Institute, Arizona State University)

  • Zhan-Gong Zhao

    (Center for Innovations in Medicine, Biodesign Institute, Arizona State University)

  • Matt Greving

    (NextVal)

  • Neal Woodbury

    (Center for Innovations in Medicine, Biodesign Institute, Arizona State University)

  • Stephen Albert Johnston

    (Center for Innovations in Medicine, Biodesign Institute, Arizona State University)

  • Phillip Stafford

    (Center for Innovations in Medicine, Biodesign Institute, Arizona State University)

Abstract

There is an increasing awareness that health care must move from post-symptomatic treatment to presymptomatic intervention. An ideal system would allow regular inexpensive monitoring of health status using circulating antibodies to report on health fluctuations. Recently, we demonstrated that peptide microarrays can do this through antibody signatures (immunosignatures). Unfortunately, printed microarrays are not scalable. Here we demonstrate a platform based on fabricating microarrays (~10 M peptides per slide, 330,000 peptides per assay) on silicon wafers using equipment common to semiconductor manufacturing. The potential of these microarrays for comprehensive health monitoring is verified through the simultaneous detection and classification of six different infectious diseases and six different cancers. Besides diagnostics, these high-density peptide chips have numerous other applications both in health care and elsewhere.

Suggested Citation

  • Joseph Barten Legutki & Zhan-Gong Zhao & Matt Greving & Neal Woodbury & Stephen Albert Johnston & Phillip Stafford, 2014. "Scalable high-density peptide arrays for comprehensive health monitoring," Nature Communications, Nature, vol. 5(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5785
    DOI: 10.1038/ncomms5785
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    1. Alejandro D. Ricci & Leonel Bracco & Emir Salas-Sarduy & Janine M. Ramsey & Melissa S. Nolan & M. Katie Lynn & Jaime Altcheh & Griselda E. Ballering & Faustino Torrico & Norival Kesper & Juan C. Villa, 2023. "The Trypanosoma cruzi Antigen and Epitope Atlas: antibody specificities in Chagas disease patients across the Americas," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    2. Yurij Ionov & Artem S Rogovskyy, 2020. "Comparison of motif-based and whole-unique-sequence-based analyses of phage display library datasets generated by biopanning of anti-Borrelia burgdorferi immune sera," PLOS ONE, Public Library of Science, vol. 15(1), pages 1-17, January.
    3. C. Raina MacIntyre & Thomas Edward Engells & Matthew Scotch & David James Heslop & Abba B. Gumel & George Poste & Xin Chen & Wesley Herche & Kathleen Steinhöfel & Samsung Lim & Alex Broom, 2018. "Converging and emerging threats to health security," Environment Systems and Decisions, Springer, vol. 38(2), pages 198-207, June.

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