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Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women

Author

Listed:
  • Kexin Chen

    (National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital)

  • Hongxia Ma

    (State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University)

  • Lian Li

    (National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital)

  • Rongyu Zang

    (Fudan University Shanghai Cancer Center)

  • Cheng Wang

    (State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University)

  • Fengju Song

    (National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital)

  • Tingyan Shi

    (Fudan University Shanghai Cancer Center
    Cancer Institute, Fudan University Shanghai Cancer Center)

  • Dianke Yu

    (Cancer Institute and Hospital, Chinese Academy of Medical Sciences)

  • Ming Yang

    (College of Life Science and Technology, Beijing University of Chemical Technology)

  • Wenqiong Xue

    (State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University)

  • Juncheng Dai

    (State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University)

  • Shuang Li

    (Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology)

  • Hong Zheng

    (National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital)

  • Chen Wu

    (Cancer Institute and Hospital, Chinese Academy of Medical Sciences)

  • Ying Zhang

    (State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University)

  • Xiaohua Wu

    (Fudan University Shanghai Cancer Center)

  • Dake Li

    (Jiangsu Province Hospital of TCM, Affiliated Hospital of Nanjing University of TCM)

  • Fengxia Xue

    (Tianjin Medical University General Hospital)

  • Haixin Li

    (National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital)

  • Zhi Jiang

    (Jiangsu Cancer Hospital, Nanjing Medical University)

  • Jibin Liu

    (Nantong Tumor Hospital)

  • Yuexin Liu

    (The University of Texas MD Anderson Cancer Center)

  • Pei Li

    (National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy of Tianjin, Tianjin Medical University Cancer Institute and Hospital)

  • Wen Tan

    (Cancer Institute and Hospital, Chinese Academy of Medical Sciences)

  • Jing Han

    (State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University)

  • Jiang Jie

    (State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University)

  • Quan Hao

    (Tianjin Medical University Cancer Institute and Hospital)

  • Zhibin Hu

    (State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University)

  • Dongxin Lin

    (Cancer Institute and Hospital, Chinese Academy of Medical Sciences)

  • Ding Ma

    (Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology)

  • Weihua Jia

    (State Key Laboratory of Oncology in Southern China, Cancer Center, Sun Yat-sen University)

  • Hongbing Shen

    (State Key Laboratory of Reproductive Medicine, Jiangsu Key Laboratory of Cancer Biomarkers, Prevention and Treatment, School of Public Health, Nanjing Medical University)

  • Qingyi Wei

    (Cancer Institute, Fudan University Shanghai Cancer Center
    Duke Cancer Institute, Duke University Medical Center)

Abstract

Ovarian cancer is the leading cause of death from gynaecological malignancies worldwide. Here we perform a three-stage genome-wide association study (GWAS) in Han Chinese women to identify risk genetic variants for epithelial ovarian cancer (EOC). We scan 900,015 single-nucleotide polymorphisms (SNPs) in 1,057 EOC cases and 1,191 controls in stage I, and replicate 41 SNPs (Pmeta

Suggested Citation

  • Kexin Chen & Hongxia Ma & Lian Li & Rongyu Zang & Cheng Wang & Fengju Song & Tingyan Shi & Dianke Yu & Ming Yang & Wenqiong Xue & Juncheng Dai & Shuang Li & Hong Zheng & Chen Wu & Ying Zhang & Xiaohua, 2014. "Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5682
    DOI: 10.1038/ncomms5682
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    Cited by:

    1. Qiuyun Wu & Weiwen Yan & Ruhui Han & Jingjin Yang & Jiali Yuan & Xiaoming Ji & Yi Liu & Chunhui Ni, 2016. "Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers’ Pneumoconiosis in a Chinese Population," IJERPH, MDPI, vol. 13(9), pages 1-8, September.
    2. Xiaoming Ji & Lijuan Wang & Baiqun Wu & Ruhui Han & Lei Han & Ting Wang & Jingjin Yang & Chunhui Ni, 2015. "Associations of MMP1 , MMP2 and MMP3 Genes Polymorphism with Coal Workers’ Pneumoconiosis in Chinese Han Population," IJERPH, MDPI, vol. 12(11), pages 1-12, October.

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