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Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers’ Pneumoconiosis in a Chinese Population

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  • Qiuyun Wu

    (Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China
    School of Public Health, Xuzhou Medical University, Xuzhou 221004, China)

  • Weiwen Yan

    (Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China)

  • Ruhui Han

    (Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China)

  • Jingjin Yang

    (Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China)

  • Jiali Yuan

    (Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China)

  • Xiaoming Ji

    (Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China)

  • Yi Liu

    (Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China)

  • Chunhui Ni

    (Department of Occupational Medicine and Environmental Health, Key Laboratory of Modern Toxicology of Ministry of Education, School of Public Health, Nanjing Medical University, Nanjing 211166, China)

Abstract

The H19 is a kind of long noncoding RNA, which has been implicated in multiple biological functions. However, the associations between genetic variants in H19 and susceptibility of coal workers’ pneumoconiosis (CWP) have been seldom reported. In the present study, three potential polymorphisms (rs2067051, rs217727, and rs2839702) in H19 were genotyped in a case-control study including 703 CWP cases and 705 controls. We found that individuals with the H19 rs2067051 CT/TT genotypes showed a decreased risk of CWP compared with those with the CC genotype (adjusted OR = 0.64, 95%CI = 0.49–0.83, p = 0.001). Further stratified analyses revealed that the associations between variant genotypes of rs2067051 and the risk of CWP were more prominent in subjects of non-smokers (adjusted OR = 0.55, 95%CI = 0.39–0.79, p = 0.001) and CWP patients with Stage I (adjusted OR = 0.63, 95%CI = 0.46–0.86, p = 0.004). Additionally, the protective effects of H19 rs2067051 were also evident in coal miners both with dust exposure years <25 years (adjusted OR = 0.63, 95%CI = 0.42–0.95, p = 0.026) and ≥25 years (adjusted OR = 0.57, 95%CI = 0.40–0.80, p = 0.001). Our results indicated that rs2067051 in the H19 gene is correlated with a deceased risk of CWP in a Chinese population, which may be a potential genetic marker for prevention and intervention of CWP. Further functional studies are warranted to validate our findings.

Suggested Citation

  • Qiuyun Wu & Weiwen Yan & Ruhui Han & Jingjin Yang & Jiali Yuan & Xiaoming Ji & Yi Liu & Chunhui Ni, 2016. "Polymorphisms in Long Noncoding RNA H19 Contribute to the Protective Effects of Coal Workers’ Pneumoconiosis in a Chinese Population," IJERPH, MDPI, vol. 13(9), pages 1-8, September.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:9:p:903-:d:78041
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    References listed on IDEAS

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    1. Kexin Chen & Hongxia Ma & Lian Li & Rongyu Zang & Cheng Wang & Fengju Song & Tingyan Shi & Dianke Yu & Ming Yang & Wenqiong Xue & Juncheng Dai & Shuang Li & Hong Zheng & Chen Wu & Ying Zhang & Xiaohua, 2014. "Genome-wide association study identifies new susceptibility loci for epithelial ovarian cancer in Han Chinese women," Nature Communications, Nature, vol. 5(1), pages 1-8, December.
    2. Xiaoming Ji & Lijuan Wang & Baiqun Wu & Ruhui Han & Lei Han & Ting Wang & Jingjin Yang & Chunhui Ni, 2015. "Associations of MMP1 , MMP2 and MMP3 Genes Polymorphism with Coal Workers’ Pneumoconiosis in Chinese Han Population," IJERPH, MDPI, vol. 12(11), pages 1-12, October.
    3. Lei Han & Ruhui Han & Xiaoming Ji & Ting Wang & Jingjin Yang & Jiali Yuan & Qiuyun Wu & Baoli Zhu & Hengdong Zhang & Bangmei Ding & Chunhui Ni, 2015. "Prevalence Characteristics of Coal Workers’ Pneumoconiosis (CWP) in a State-Owned Mine in Eastern China," IJERPH, MDPI, vol. 12(7), pages 1-12, July.
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    More about this item

    Keywords

    genetics; polymorphisms; coal workers’ pneumoconiosis; long noncoding RNA; H19;
    All these keywords.

    JEL classification:

    • H19 - Public Economics - - Structure and Scope of Government - - - Other

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