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Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits

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  • Mary F. Durham

    (University of Maryland, Baltimore County)

  • Michael M. Magwire

    (North Carolina State University)

  • Eric A. Stone

    (North Carolina State University)

  • Jeff Leips

    (University of Maryland, Baltimore County)

Abstract

Most organisms exhibit senescence; a decline in physiological function with age. In nature, rates of senescence vary extensively among individuals and this variation has a significant genetic component; however, we know little about the genes underlying senescence. Here we show the first evidence that individual alleles influence fecundity in an age-specific manner and so the genetic basis of natural variation in fecundity changes dramatically with age. We complete a genome-wide association to identify single-nucleotide polymorphisms (SNPs) affecting lifespan and age-specific fecundity using the Drosophila melanogaster Genetic Reference Panel. We identify 1,031 SNPs affecting fecundity and 52 influencing lifespan. Only one SNP is associated with both early- and late-age fecundity. The age-specific effect of candidate genes on fecundity is validated using RNA interference. In addition, there is a dramatic increase in the number of SNPs influencing fecundity with age. This result provides support for the mutation accumulation theory of aging.

Suggested Citation

  • Mary F. Durham & Michael M. Magwire & Eric A. Stone & Jeff Leips, 2014. "Genome-wide analysis in Drosophila reveals age-specific effects of SNPs on fitness traits," Nature Communications, Nature, vol. 5(1), pages 1-8, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms5338
    DOI: 10.1038/ncomms5338
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    Cited by:

    1. Stefano Giaimo & Arne Traulsen, 2022. "The selection force weakens with age because ageing evolves and not vice versa," Nature Communications, Nature, vol. 13(1), pages 1-7, December.

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