IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms4746.html
   My bibliography  Save this article

Maternal nutrition at conception modulates DNA methylation of human metastable epialleles

Author

Listed:
  • Paula Dominguez-Salas

    (MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street)

  • Sophie E. Moore

    (MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street)

  • Maria S. Baker

    (Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center)

  • Andrew W. Bergen

    (Center for Health Sciences, SRI International)

  • Sharon E. Cox

    (MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street)

  • Roger A. Dyer

    (University of British Columbia)

  • Anthony J. Fulford

    (MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street)

  • Yongtao Guan

    (Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center
    Baylor College of Medicine)

  • Eleonora Laritsky

    (Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center)

  • Matt J. Silver

    (MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street)

  • Gary E. Swan

    (Stanford Prevention Research Center, Stanford University School of Medicine)

  • Steven H. Zeisel

    (Nutrition Research Institute, Gillings School of Global Public Health and School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill)

  • Sheila M. Innis

    (University of British Columbia)

  • Robert A. Waterland

    (Baylor College of Medicine, USDA/ARS Children's Nutrition Research Center
    Baylor College of Medicine)

  • Andrew M. Prentice

    (MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street)

  • Branwen J. Hennig

    (MRC International Nutrition Group at MRC Keneba, The Gambia and London School of Hygiene & Tropical Medicine, EPH, LSHTM, Keppel Street)

Abstract

In experimental animals, maternal diet during the periconceptional period influences the establishment of DNA methylation at metastable epialleles in the offspring, with permanent phenotypic consequences. Pronounced naturally occurring seasonal differences in the diet of rural Gambian women allowed us to test this in humans. We show that significant seasonal variations in methyl-donor nutrient intake of mothers around the time of conception influence 13 relevant plasma biomarkers. The level of several of these maternal biomarkers predicts increased/decreased methylation at metastable epialleles in DNA extracted from lymphocytes and hair follicles in infants postnatally. Our results demonstrate that maternal nutritional status during early pregnancy causes persistent and systemic epigenetic changes at human metastable epialleles.

Suggested Citation

  • Paula Dominguez-Salas & Sophie E. Moore & Maria S. Baker & Andrew W. Bergen & Sharon E. Cox & Roger A. Dyer & Anthony J. Fulford & Yongtao Guan & Eleonora Laritsky & Matt J. Silver & Gary E. Swan & St, 2014. "Maternal nutrition at conception modulates DNA methylation of human metastable epialleles," Nature Communications, Nature, vol. 5(1), pages 1-7, September.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4746
    DOI: 10.1038/ncomms4746
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms4746
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms4746?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Amir D. Hay & Noah J. Kessler & Daniel Gebert & Nozomi Takahashi & Hugo Tavares & Felipe K. Teixeira & Anne C. Ferguson-Smith, 2023. "Epigenetic inheritance is unfaithful at intermediately methylated CpG sites," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    2. International Food Policy Research Institute, 2015. "Global Nutrition Report Actions and Accountability to Advance Nutrition and Sustainable Development," Working Papers id:7543, eSocialSciences.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4746. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.