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Porphyrin–phospholipid liposomes permeabilized by near-infrared light

Author

Listed:
  • Kevin A. Carter

    (University at Buffalo, State University of New York
    University at Buffalo, State University of New York)

  • Shuai Shao

    (University at Buffalo, State University of New York
    University at Buffalo, State University of New York)

  • Matthew I. Hoopes

    (University of Waterloo)

  • Dandan Luo

    (University at Buffalo, State University of New York)

  • Bilal Ahsan

    (McMaster University)

  • Vladimir M. Grigoryants

    (University at Albany, State University of New York)

  • Wentao Song

    (University at Buffalo, State University of New York)

  • Haoyuan Huang

    (University at Buffalo, State University of New York
    University at Buffalo, State University of New York)

  • Guojian Zhang

    (University at Buffalo, State University of New York)

  • Ravindra K. Pandey

    (PDT Center, Roswell Park Cancer Institute)

  • Jumin Geng

    (University at Buffalo, State University of New York)

  • Blaine A. Pfeifer

    (University at Buffalo, State University of New York)

  • Charles P. Scholes

    (University at Albany, State University of New York)

  • Joaquin Ortega

    (McMaster University)

  • Mikko Karttunen

    (University of Waterloo)

  • Jonathan F. Lovell

    (University at Buffalo, State University of New York
    University at Buffalo, State University of New York)

Abstract

The delivery of therapeutic compounds to target tissues is a central challenge in treating disease. Externally controlled drug release systems hold potential to selectively enhance localized delivery. Here we describe liposomes doped with porphyrin–phospholipid that are permeabilized directly by near-infrared light. Molecular dynamics simulations identified a novel light-absorbing monomer esterified from clinically approved components predicted and experimentally demonstrated to give rise to a more stable porphyrin bilayer. Light-induced membrane permeabilization is enabled with liposomal inclusion of 10 molar % porphyrin–phospholipid and occurs in the absence of bulk or nanoscale heating. Liposomes reseal following laser exposure and permeability is modulated by varying porphyrin–phospholipid doping, irradiation intensity or irradiation duration. Porphyrin–phospholipid liposomes demonstrate spatial control of release of entrapped gentamicin and temporal control of release of entrapped fluorophores following intratumoral injection. Following systemic administration, laser irradiation enhances deposition of actively loaded doxorubicin in mouse xenografts, enabling an effective single-treatment antitumour therapy.

Suggested Citation

  • Kevin A. Carter & Shuai Shao & Matthew I. Hoopes & Dandan Luo & Bilal Ahsan & Vladimir M. Grigoryants & Wentao Song & Haoyuan Huang & Guojian Zhang & Ravindra K. Pandey & Jumin Geng & Blaine A. Pfeife, 2014. "Porphyrin–phospholipid liposomes permeabilized by near-infrared light," Nature Communications, Nature, vol. 5(1), pages 1-11, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4546
    DOI: 10.1038/ncomms4546
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    Cited by:

    1. Jiyuan Li & Qi Sun & Chuanjie Lu & Han Xiao & Zhibin Guo & Dongban Duan & Zizhu Zhang & Tong Liu & Zhibo Liu, 2022. "Boron encapsulated in a liposome can be used for combinational neutron capture therapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.

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