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Boron encapsulated in a liposome can be used for combinational neutron capture therapy

Author

Listed:
  • Jiyuan Li

    (Peking University)

  • Qi Sun

    (Peking University-Tsinghua University Center for Life Sciences)

  • Chuanjie Lu

    (Peking University)

  • Han Xiao

    (University of Chinese Academy of Sciences Beijing)

  • Zhibin Guo

    (Peking University)

  • Dongban Duan

    (Peking University)

  • Zizhu Zhang

    (Beijing Nuclear Industry Hospital
    Beijing Capture Tech Co., Ltd)

  • Tong Liu

    (Beijing Capture Tech Co., Ltd)

  • Zhibo Liu

    (Peking University
    Peking University-Tsinghua University Center for Life Sciences)

Abstract

Boron neutron capture therapy (BNCT) is an attractive approach to treat invasive malignant tumours due to binary heavy-particle irradiation, but its clinical applications have been hindered by boron delivery agents with low in vivo stability, poor biocompatibility, and limited application of combinational modalities. Here, we report boronsome, a carboranyl-phosphatidylcholine based liposome for combinational BNCT and chemotherapy. Theoretical simulations and experimental approaches illustrate high stability of boronsome. Then positron emission tomography (PET) imaging with Cu-64 labelled boronsome reveals high-specific tumour accumulation and long retention with a clear irradiation background. In particular, we show the suppression of tumour growth treated with boronsome with neutron irradiation and therapeutic outcomes are further improved by encapsulation of chemotherapy drugs, especially with PARP1 inhibitors. In sum, boronsome may be an efficient agent for concurrent chemoradiotherapy with theranostic properties against malignancies.

Suggested Citation

  • Jiyuan Li & Qi Sun & Chuanjie Lu & Han Xiao & Zhibin Guo & Dongban Duan & Zizhu Zhang & Tong Liu & Zhibo Liu, 2022. "Boron encapsulated in a liposome can be used for combinational neutron capture therapy," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:13:y:2022:i:1:d:10.1038_s41467-022-29780-w
    DOI: 10.1038/s41467-022-29780-w
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    References listed on IDEAS

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    1. Kevin A. Carter & Shuai Shao & Matthew I. Hoopes & Dandan Luo & Bilal Ahsan & Vladimir M. Grigoryants & Wentao Song & Haoyuan Huang & Guojian Zhang & Ravindra K. Pandey & Jumin Geng & Blaine A. Pfeife, 2014. "Porphyrin–phospholipid liposomes permeabilized by near-infrared light," Nature Communications, Nature, vol. 5(1), pages 1-11, May.
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