IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v5y2014i1d10.1038_ncomms4346.html
   My bibliography  Save this article

African origin of the malaria parasite Plasmodium vivax

Author

Listed:
  • Weimin Liu

    (University of Pennsylvania)

  • Yingying Li

    (University of Pennsylvania)

  • Katharina S. Shaw

    (Columbia University)

  • Gerald H. Learn

    (University of Pennsylvania)

  • Lindsey J. Plenderleith

    (Institute of Evolutionary Biology, University of Edinburgh)

  • Jordan A. Malenke

    (University of Pennsylvania)

  • Sesh A. Sundararaman

    (University of Pennsylvania
    University of Pennsylvania)

  • Miguel A. Ramirez

    (University of Pennsylvania)

  • Patricia A. Crystal

    (University of Pennsylvania)

  • Andrew G. Smith

    (University of Pennsylvania)

  • Frederic Bibollet-Ruche

    (University of Pennsylvania)

  • Ahidjo Ayouba

    (Unité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1)

  • Sabrina Locatelli

    (Unité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1)

  • Amandine Esteban

    (Unité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1)

  • Fatima Mouacha

    (Unité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1)

  • Emilande Guichet

    (Unité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1)

  • Christelle Butel

    (Unité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1)

  • Steve Ahuka-Mundeke

    (Unité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1
    Institut National de Recherche Biomedicale)

  • Bila-Isia Inogwabini

    (Swedish University of Agricultural Sciences)

  • Jean-Bosco N. Ndjango

    (Faculty of Sciences, University of Kisangani)

  • Sheri Speede

    (Sanaga-Yong Chimpanzee Rescue Center)

  • Crickette M. Sanz

    (Washington University
    Wildlife Conservation Society, Congo Program)

  • David B. Morgan

    (Wildlife Conservation Society, Congo Program
    Lester E. Fisher Center for the Study and Conservation of Apes, Lincoln Park Zoo)

  • Mary K. Gonder

    (University at Albany, State University of New York)

  • Philip J. Kranzusch

    (University of California)

  • Peter D. Walsh

    (University of Cambridge)

  • Alexander V. Georgiev

    (Harvard University
    Present address: Institute for Mind and Biology, The University of Chicago, Chicago, Illinois 60637, USA)

  • Martin N. Muller

    (University of New Mexico)

  • Alex K. Piel

    (University of Cambridge
    University of California)

  • Fiona A. Stewart

    (University of Cambridge)

  • Michael L. Wilson

    (University of Minnesota)

  • Anne E. Pusey

    (Duke University)

  • Liwang Cui

    (Pennsylvania State University, University Park)

  • Zenglei Wang

    (Pennsylvania State University, University Park)

  • Anna Färnert

    (Infectious Disease Unit, Karolinska Institute, Karolinska University Hospital)

  • Colin J. Sutherland

    (Public Health England Malaria Reference Laboratory, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine)

  • Debbie Nolder

    (Public Health England Malaria Reference Laboratory, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine)

  • John A. Hart

    (Lukuru Wildlife Research Foundation, Tshuapa-Lomami-Lualaba Project)

  • Terese B. Hart

    (Lukuru Wildlife Research Foundation, Tshuapa-Lomami-Lualaba Project)

  • Paco Bertolani

    (Leverhulme Centre for Human Evolutionary Studies, University of Cambridge)

  • Amethyst Gillis

    (Global Viral Forecasting Initiative)

  • Matthew LeBreton

    (Global Viral Forecasting Initiative)

  • Babila Tafon

    (Ape Action Africa)

  • John Kiyang

    (Limbe Wildlife Centre)

  • Cyrille F. Djoko

    (Global Viral Forecasting Initiative)

  • Bradley S. Schneider

    (Global Viral Forecasting Initiative)

  • Nathan D. Wolfe

    (Global Viral Forecasting Initiative)

  • Eitel Mpoudi-Ngole

    (Institut de Recherches Médicales et d’Études des Plantes Médicinales Prévention du Sida au Cameroun, Centre de Recherche Médicale)

  • Eric Delaporte

    (Unité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1)

  • Richard Carter

    (Institute of Immunology and Infection Research, University of Edinburgh
    Centre for Immunity, Infection and Evolution, University of Edinburgh)

  • Richard L. Culleton

    (Malaria Unit, Institute of Tropical Medicine, Nagasaki University)

  • George M. Shaw

    (University of Pennsylvania
    University of Pennsylvania)

  • Julian C. Rayner

    (Malaria Programme, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus)

  • Martine Peeters

    (Unité Mixte Internationale 233 Institut de Recherche pour le Développement and University of Montpellier 1)

  • Beatrice H. Hahn

    (University of Pennsylvania
    University of Pennsylvania)

  • Paul M. Sharp

    (Institute of Evolutionary Biology, University of Edinburgh
    Centre for Immunity, Infection and Evolution, University of Edinburgh)

Abstract

Plasmodium vivax is the leading cause of human malaria in Asia and Latin America but is absent from most of central Africa due to the near fixation of a mutation that inhibits the expression of its receptor, the Duffy antigen, on human erythrocytes. The emergence of this protective allele is not understood because P. vivax is believed to have originated in Asia. Here we show, using a non-invasive approach, that wild chimpanzees and gorillas throughout central Africa are endemically infected with parasites that are closely related to human P. vivax. Sequence analyses reveal that ape parasites lack host specificity and are much more diverse than human parasites, which form a monophyletic lineage within the ape parasite radiation. These findings indicate that human P. vivax is of African origin and likely selected for the Duffy-negative mutation. All extant human P. vivax parasites are derived from a single ancestor that escaped out of Africa.

Suggested Citation

  • Weimin Liu & Yingying Li & Katharina S. Shaw & Gerald H. Learn & Lindsey J. Plenderleith & Jordan A. Malenke & Sesh A. Sundararaman & Miguel A. Ramirez & Patricia A. Crystal & Andrew G. Smith & Freder, 2014. "African origin of the malaria parasite Plasmodium vivax," Nature Communications, Nature, vol. 5(1), pages 1-10, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4346
    DOI: 10.1038/ncomms4346
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms4346
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms4346?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Lindsey J. Plenderleith & Weimin Liu & Yingying Li & Dorothy E. Loy & Ewan Mollison & Jesse Connell & Ahidjo Ayouba & Amandine Esteban & Martine Peeters & Crickette M. Sanz & David B. Morgan & Nathan , 2022. "Zoonotic origin of the human malaria parasite Plasmodium malariae from African apes," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    2. Emily E. Wroblewski & Lisbeth A. Guethlein & Aaron G. Anderson & Weimin Liu & Yingying Li & Sara E. Heisel & Andrew Jesse Connell & Jean-Bosco N. Ndjango & Paco Bertolani & John A. Hart & Terese B. Ha, 2023. "Malaria-driven adaptation of MHC class I in wild bonobo populations," Nature Communications, Nature, vol. 14(1), pages 1-11, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4346. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.