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Malaria-driven adaptation of MHC class I in wild bonobo populations

Author

Listed:
  • Emily E. Wroblewski

    (Washington University in St. Louis)

  • Lisbeth A. Guethlein

    (Stanford University School of Medicine)

  • Aaron G. Anderson

    (Washington University in St. Louis)

  • Weimin Liu

    (University of Pennsylvania)

  • Yingying Li

    (University of Pennsylvania)

  • Sara E. Heisel

    (Washington University in St. Louis)

  • Andrew Jesse Connell

    (University of Pennsylvania
    University of Pennsylvania)

  • Jean-Bosco N. Ndjango

    (University of Kisangani)

  • Paco Bertolani

    (University of Oxford)

  • John A. Hart

    (Frankfurt Zoological Society, Lomami National Park Project)

  • Terese B. Hart

    (Frankfurt Zoological Society, Lomami National Park Project)

  • Crickette M. Sanz

    (Washington University in St. Louis
    Congo Program, Wildlife Conservation Society)

  • David B. Morgan

    (Lester E. Fisher Center for the Study and Conservation of Apes, Lincoln Park Zoo)

  • Martine Peeters

    (University of Montpellier, INSERM)

  • Paul M. Sharp

    (University of Edinburgh
    University of Edinburgh)

  • Beatrice H. Hahn

    (University of Pennsylvania
    University of Pennsylvania)

  • Peter Parham

    (Stanford University School of Medicine
    Stanford University School of Medicine)

Abstract

The malaria parasite Plasmodium falciparum causes substantial human mortality, primarily in equatorial Africa. Enriched in affected African populations, the B*53 variant of HLA-B, a cell surface protein that presents peptide antigens to cytotoxic lymphocytes, confers protection against severe malaria. Gorilla, chimpanzee, and bonobo are humans’ closest living relatives. These African apes have HLA-B orthologs and are infected by parasites in the same subgenus (Laverania) as P. falciparum, but the consequences of these infections are unclear. Laverania parasites infect bonobos (Pan paniscus) at only one (TL2) of many sites sampled across their range. TL2 spans the Lomami River and has genetically divergent subpopulations of bonobos on each side. Papa-B, the bonobo ortholog of HLA-B, includes variants having a B*53-like (B07) peptide-binding supertype profile. Here we show that B07 Papa-B occur at high frequency in TL2 bonobos and that malaria appears to have independently selected for different B07 alleles in the two subpopulations.

Suggested Citation

  • Emily E. Wroblewski & Lisbeth A. Guethlein & Aaron G. Anderson & Weimin Liu & Yingying Li & Sara E. Heisel & Andrew Jesse Connell & Jean-Bosco N. Ndjango & Paco Bertolani & John A. Hart & Terese B. Ha, 2023. "Malaria-driven adaptation of MHC class I in wild bonobo populations," Nature Communications, Nature, vol. 14(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-36623-9
    DOI: 10.1038/s41467-023-36623-9
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    References listed on IDEAS

    as
    1. Weimin Liu & Scott Sherrill-Mix & Gerald H. Learn & Erik J. Scully & Yingying Li & Alexa N. Avitto & Dorothy E. Loy & Abigail P. Lauder & Sesh A. Sundararaman & Lindsey J. Plenderleith & Jean-Bosco N., 2017. "Wild bonobos host geographically restricted malaria parasites including a putative new Laverania species," Nature Communications, Nature, vol. 8(1), pages 1-14, December.
    2. Weimin Liu & Yingying Li & Katharina S. Shaw & Gerald H. Learn & Lindsey J. Plenderleith & Jordan A. Malenke & Sesh A. Sundararaman & Miguel A. Ramirez & Patricia A. Crystal & Andrew G. Smith & Freder, 2014. "African origin of the malaria parasite Plasmodium vivax," Nature Communications, Nature, vol. 5(1), pages 1-10, May.
    3. Weimin Liu & Yingying Li & Gerald H. Learn & Rebecca S. Rudicell & Joel D. Robertson & Brandon F. Keele & Jean-Bosco N. Ndjango & Crickette M. Sanz & David B. Morgan & Sabrina Locatelli & Mary K. Gond, 2010. "Origin of the human malaria parasite Plasmodium falciparum in gorillas," Nature, Nature, vol. 467(7314), pages 420-425, September.
    4. Michael L. Wilson & Christophe Boesch & Barbara Fruth & Takeshi Furuichi & Ian C. Gilby & Chie Hashimoto & Catherine L. Hobaiter & Gottfried Hohmann & Noriko Itoh & Kathelijne Koops & Julia N. Lloyd &, 2014. "Lethal aggression in Pan is better explained by adaptive strategies than human impacts," Nature, Nature, vol. 513(7518), pages 414-417, September.
    5. Javier Prado-Martinez & Peter H. Sudmant & Jeffrey M. Kidd & Heng Li & Joanna L. Kelley & Belen Lorente-Galdos & Krishna R. Veeramah & August E. Woerner & Timothy D. O’Connor & Gabriel Santpere & Alex, 2013. "Great ape genetic diversity and population history," Nature, Nature, vol. 499(7459), pages 471-475, July.
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