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MED18 interaction with distinct transcription factors regulates multiple plant functions

Author

Listed:
  • Zhibing Lai

    (Purdue University)

  • Craig M. Schluttenhofer

    (Purdue University
    Present address: University of Kentucky, Plant Science Building, 1405 Veterans Drive, Lexington, Kentucky 40546-0312, USA)

  • Ketaki Bhide

    (Bioinformatics Core, Cyber Center, Discovery Park, Purdue University)

  • Jacob Shreve

    (Bioinformatics Core, Cyber Center, Discovery Park, Purdue University)

  • Jyothi Thimmapuram

    (Bioinformatics Core, Cyber Center, Discovery Park, Purdue University)

  • Sang Yeol Lee

    (Gyeongsang National University)

  • Dae-Jin Yun

    (Gyeongsang National University)

  • Tesfaye Mengiste

    (Purdue University)

Abstract

Mediator is an evolutionarily conserved transcriptional regulatory complex. Mechanisms of Mediator function are poorly understood. Here we show that Arabidopsis MED18 is a multifunctional protein regulating plant immunity, flowering time and responses to hormones through interactions with distinct transcription factors. MED18 interacts with YIN YANG1 to suppress disease susceptibility genes glutaredoxins GRX480, GRXS13 and thioredoxin TRX-h5. Consequently, yy1 and med18 mutants exhibit deregulated expression of these genes and enhanced susceptibility to fungal infection. In addition, MED18 interacts with ABA INSENSITIVE 4 and SUPPRESSOR OF FRIGIDA4 to regulate abscisic acid responses and flowering time, respectively. MED18 associates with the promoter, coding and terminator regions of target genes suggesting its function in transcription initiation, elongation and termination. Notably, RNA polymerase II occupancy and histone H3 lysine tri-methylation of target genes are affected in the med18 mutant, reinforcing MED18 function in different mechanisms of transcriptional control. Overall, MED18 conveys distinct cues to engender transcription underpinning plant responses.

Suggested Citation

  • Zhibing Lai & Craig M. Schluttenhofer & Ketaki Bhide & Jacob Shreve & Jyothi Thimmapuram & Sang Yeol Lee & Dae-Jin Yun & Tesfaye Mengiste, 2014. "MED18 interaction with distinct transcription factors regulates multiple plant functions," Nature Communications, Nature, vol. 5(1), pages 1-14, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4064
    DOI: 10.1038/ncomms4064
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    Cited by:

    1. Fangming Wu & Chuanlong Sun & Ziying Zhu & Lei Deng & Feifei Yu & Qi Xie & Chuanyou Li, 2025. "A multiprotein regulatory module, MED16–MBR1&2, controls MED25 homeostasis during jasmonate signaling," Nature Communications, Nature, vol. 16(1), pages 1-16, December.

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