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Biomimetic virus-based colourimetric sensors

Author

Listed:
  • Jin-Woo Oh

    (University of California
    Lawrence Berkeley National Laboratory
    Pusan National University
    Pusan National University)

  • Woo-Jae Chung

    (University of California
    Lawrence Berkeley National Laboratory
    College of Biotechnology and Bioengineering, Sungkyunkwan University)

  • Kwang Heo

    (University of California
    Lawrence Berkeley National Laboratory)

  • Hyo-Eon Jin

    (University of California
    Lawrence Berkeley National Laboratory)

  • Byung Yang Lee

    (University of California
    Lawrence Berkeley National Laboratory
    Korea University)

  • Eddie Wang

    (University of California
    Lawrence Berkeley National Laboratory)

  • Chris Zueger

    (University of California
    Lawrence Berkeley National Laboratory)

  • Winnie Wong

    (University of California
    Lawrence Berkeley National Laboratory)

  • Joel Meyer

    (University of California
    Lawrence Berkeley National Laboratory)

  • Chuntae Kim

    (Pusan National University)

  • So-Young Lee

    (Pusan National University)

  • Won-Geun Kim

    (Pusan National University)

  • Marcin Zemla

    (Lawrence Berkeley National Laboratory)

  • Manfred Auer

    (Lawrence Berkeley National Laboratory)

  • Alexander Hexemer

    (Advanced Light Source, Lawrence Berkeley National Laboratory)

  • Seung-Wuk Lee

    (University of California
    Lawrence Berkeley National Laboratory)

Abstract

Many materials in nature change colours in response to stimuli, making them attractive for use as sensor platform. However, both natural materials and their synthetic analogues lack selectivity towards specific chemicals, and introducing such selectivity remains a challenge. Here we report the self-assembly of genetically engineered viruses (M13 phage) into target-specific, colourimetric biosensors. The sensors are composed of phage-bundle nanostructures and exhibit viewing-angle independent colour, similar to collagen structures in turkey skin. On exposure to various volatile organic chemicals, the structures rapidly swell and undergo distinct colour changes. Furthermore, sensors composed of phage displaying trinitrotoluene (TNT)-binding peptide motifs identified from a phage display selectively distinguish TNT down to 300 p.p.b. over similarly structured chemicals. Our tunable, colourimetric sensors can be useful for the detection of a variety of harmful toxicants and pathogens to protect human health and national security.

Suggested Citation

  • Jin-Woo Oh & Woo-Jae Chung & Kwang Heo & Hyo-Eon Jin & Byung Yang Lee & Eddie Wang & Chris Zueger & Winnie Wong & Joel Meyer & Chuntae Kim & So-Young Lee & Won-Geun Kim & Marcin Zemla & Manfred Auer &, 2014. "Biomimetic virus-based colourimetric sensors," Nature Communications, Nature, vol. 5(1), pages 1-8, May.
    • Handle: RePEc:nat:natcom:v:5:y:2014:i:1:d:10.1038_ncomms4043
    DOI: 10.1038/ncomms4043
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    Cited by:

    1. Lei Tian & Leon He & Kyle Jackson & Ahmed Saif & Shadman Khan & Zeqi Wan & Tohid F. Didar & Zeinab Hosseinidoust, 2022. "Self-assembling nanofibrous bacteriophage microgels as sprayable antimicrobials targeting multidrug-resistant bacteria," Nature Communications, Nature, vol. 13(1), pages 1-12, December.

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