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Ultrashort single-walled carbon nanotubes in a lipid bilayer as a new nanopore sensor

Author

Listed:
  • Lei Liu

    (Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences)

  • Chun Yang

    (Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences)

  • Kai Zhao

    (Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences)

  • Jingyuan Li

    (Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences)

  • Hai-Chen Wu

    (Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences)

Abstract

An important issue in nanopore sensing is to construct stable and versatile sensors that can discriminate analytes with minute differences. Here we report a means of creating nanopores that comprise ultrashort single-walled carbon nanotubes inserted into a lipid bilayer. We investigate the ion transport and DNA translocation through single-walled carbon nanotube nanopores and find that our results are fundamentally different from previous studies using much longer single-walled carbon nanotubes. Furthermore, we utilize the new single-walled carbon nanotube nanopores to selectively detect modified 5-hydroxymethylcytosine in single-stranded DNA, which may have implications in screening specific genomic DNA sequences. This new nanopore platform can be integrated with many unique properties of carbon nanotubes and might be useful in molecular sensing such as DNA-damage detection, nanopore DNA sequencing and other nanopore-based applications.

Suggested Citation

  • Lei Liu & Chun Yang & Kai Zhao & Jingyuan Li & Hai-Chen Wu, 2013. "Ultrashort single-walled carbon nanotubes in a lipid bilayer as a new nanopore sensor," Nature Communications, Nature, vol. 4(1), pages 1-8, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3989
    DOI: 10.1038/ncomms3989
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    Cited by:

    1. Weichao Peng & Shuaihu Yan & Ke Zhou & Hai-Chen Wu & Lei Liu & Yuliang Zhao, 2023. "High-resolution discrimination of homologous and isomeric proteinogenic amino acids in nanopore sensors with ultrashort single-walled carbon nanotubes," Nature Communications, Nature, vol. 14(1), pages 1-8, December.

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