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Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila

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  • Junbo Liu

    (Cincinnati Children’s Research Foundation)

  • Jun Ma

    (Cincinnati Children’s Research Foundation
    Cincinnati Children’s Research Foundation)

Abstract

The Drosophila morphogen gradient of Bicoid (Bcd) initiates anterior–posterior (AP) patterning; however, it is poorly understood how its ability to activate a target gene may have an impact on this process. Here we report an F-box protein, Dampened (Dmpd) as a nuclear cofactor of Bcd that can enhance its activating potency. We establish a quantitative platform to specifically investigate two parameters of a Bcd target gene response, expression amplitude and boundary position. We show that embryos lacking Dmpd have a reduced amplitude of Bcd-activated hunchback (hb) expression at a critical time of development. This is because of a reduced Bcd-dependent transcribing probability. This defect is faithfully propagated further downstream of the AP-patterning network to alter the spatial characteristics of even-skipped (eve) stripes. Thus, unlike another Bcd-interacting F-box protein Fate-shifted (Fsd), which controls AP patterning through regulating the Bcd gradient profile, Dmpd achieves its patterning role through regulating the activating potency of Bcd.

Suggested Citation

  • Junbo Liu & Jun Ma, 2013. "Dampened regulates the activating potency of Bicoid and the embryonic patterning outcome in Drosophila," Nature Communications, Nature, vol. 4(1), pages 1-11, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3968
    DOI: 10.1038/ncomms3968
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    Cited by:

    1. Jingyao Wang & Shihe Zhang & Hongfang Lu & Heng Xu, 2022. "Differential regulation of alternative promoters emerges from unified kinetics of enhancer-promoter interaction," Nature Communications, Nature, vol. 13(1), pages 1-14, December.

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