IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v4y2013i1d10.1038_ncomms3575.html
   My bibliography  Save this article

Structural and functional characterization of two alpha-synuclein strains

Author

Listed:
  • Luc Bousset

    (Laboratoire d’Enzymologie et Biochimie Structurales, CNRS)

  • Laura Pieri

    (Laboratoire d’Enzymologie et Biochimie Structurales, CNRS)

  • Gemma Ruiz-Arlandis

    (Laboratoire d’Enzymologie et Biochimie Structurales, CNRS)

  • Julia Gath

    (Physical Chemistry, ETH Zurich)

  • Poul Henning Jensen

    (Aarhus University)

  • Birgit Habenstein

    (Institut de Biologie et Chimie des Proteines, CNRS/Universite de Lyon 1)

  • Karine Madiona

    (Laboratoire d’Enzymologie et Biochimie Structurales, CNRS)

  • Vincent Olieric

    (Swiss Light Source, Paul Scherrer Institute)

  • Anja Böckmann

    (Institut de Biologie et Chimie des Proteines, CNRS/Universite de Lyon 1)

  • Beat H. Meier

    (Physical Chemistry, ETH Zurich)

  • Ronald Melki

    (Laboratoire d’Enzymologie et Biochimie Structurales, CNRS)

Abstract

α-synuclein aggregation is implicated in a variety of diseases including Parkinson’s disease, dementia with Lewy bodies, pure autonomic failure and multiple system atrophy. The association of protein aggregates made of a single protein with a variety of clinical phenotypes has been explained for prion diseases by the existence of different strains that propagate through the infection pathway. Here we structurally and functionally characterize two polymorphs of α-synuclein. We present evidence that the two forms indeed fulfil the molecular criteria to be identified as two strains of α-synuclein. Specifically, we show that the two strains have different structures, levels of toxicity, and in vitro and in vivo seeding and propagation properties. Such strain differences may account for differences in disease progression in different individuals/cell types and/or types of synucleinopathies.

Suggested Citation

  • Luc Bousset & Laura Pieri & Gemma Ruiz-Arlandis & Julia Gath & Poul Henning Jensen & Birgit Habenstein & Karine Madiona & Vincent Olieric & Anja Böckmann & Beat H. Meier & Ronald Melki, 2013. "Structural and functional characterization of two alpha-synuclein strains," Nature Communications, Nature, vol. 4(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3575
    DOI: 10.1038/ncomms3575
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms3575
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/ncomms3575?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Derya Emin & Yu P. Zhang & Evgeniia Lobanova & Alyssa Miller & Xuecong Li & Zengjie Xia & Helen Dakin & Dimitrios I. Sideris & Jeff Y. L. Lam & Rohan T. Ranasinghe & Antonina Kouli & Yanyan Zhao & Sum, 2022. "Small soluble α-synuclein aggregates are the toxic species in Parkinson’s disease," Nature Communications, Nature, vol. 13(1), pages 1-15, December.
    2. Jemil Ahmed & Tessa C. Fitch & Courtney M. Donnelly & Johnson A. Joseph & Tyler D. Ball & Mikaela M. Bassil & Ahyun Son & Chen Zhang & Aurélie Ledreux & Scott Horowitz & Yan Qin & Daniel Paredes & Sun, 2022. "Foldamers reveal and validate therapeutic targets associated with toxic α-synuclein self-assembly," Nature Communications, Nature, vol. 13(1), pages 1-17, December.
    3. Dhruva D. Dhavale & Alexander M. Barclay & Collin G. Borcik & Katherine Basore & Deborah A. Berthold & Isabelle R. Gordon & Jialu Liu & Moses H. Milchberg & Jennifer Y. O’Shea & Michael J. Rau & Zacha, 2024. "Structure of alpha-synuclein fibrils derived from human Lewy body dementia tissue," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    4. Nicholas H. Stillman & Johnson A. Joseph & Jemil Ahmed & Charles Zuwu Baysah & Ryan A. Dohoney & Tyler D. Ball & Alexandra G. Thomas & Tessa C. Fitch & Courtney M. Donnelly & Sunil Kumar, 2024. "Protein mimetic 2D FAST rescues alpha synuclein aggregation mediated early and post disease Parkinson’s phenotypes," Nature Communications, Nature, vol. 15(1), pages 1-25, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3575. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.