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A platform for designing hyperpolarized magnetic resonance chemical probes

Author

Listed:
  • Hiroshi Nonaka

    (INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku)

  • Ryunosuke Hata

    (INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku)

  • Tomohiro Doura

    (INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku)

  • Tatsuya Nishihara

    (INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku)

  • Keiko Kumagai

    (Science Research Center, Kochi University)

  • Mai Akakabe

    (Science Research Center, Kochi University)

  • Masashi Tsuda

    (Center for Advanced Marine Core Research, Kochi University)

  • Kazuhiro Ichikawa

    (Innovation Center for Medical Redox Navigation, Kyushu University)

  • Shinsuke Sando

    (INAMORI Frontier Research Center, Kyushu University, 744 Motooka, Nishi-ku
    Innovation Center for Medical Redox Navigation, Kyushu University)

Abstract

Hyperpolarization is a highly promising technique for improving the sensitivity of magnetic resonance chemical probes. Here we report [15N, D9]trimethylphenylammonium as a platform for designing a variety of hyperpolarized magnetic resonance chemical probes. The platform structure shows a remarkably long 15N spin–lattice relaxation value (816 s, 14.1 T) for retaining its hyperpolarized spin state. The extended lifetime enables the detection of the hyperpolarized 15N signal of the platform for several tens of minutes and thus overcomes the intrinsic short analysis time of hyperpolarized probes. Versatility of the platform is demonstrated by applying it to three types of hyperpolarized chemical probes: one each for sensing calcium ions, reactive oxygen species (hydrogen peroxide) and enzyme activity (carboxyl esterase). All of the designed probes achieve high sensitivity with rapid reactions and chemical shift changes, which are sufficient to allow sensitive and real-time monitoring of target molecules by 15N magnetic resonance.

Suggested Citation

  • Hiroshi Nonaka & Ryunosuke Hata & Tomohiro Doura & Tatsuya Nishihara & Keiko Kumagai & Mai Akakabe & Masashi Tsuda & Kazuhiro Ichikawa & Shinsuke Sando, 2013. "A platform for designing hyperpolarized magnetic resonance chemical probes," Nature Communications, Nature, vol. 4(1), pages 1-7, December.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3411
    DOI: 10.1038/ncomms3411
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    Cited by:

    1. Yusuke Kawashima & Tomoyuki Hamachi & Akio Yamauchi & Koki Nishimura & Yuma Nakashima & Saiya Fujiwara & Nobuo Kimizuka & Tomohiro Ryu & Tetsu Tamura & Masaki Saigo & Ken Onda & Shunsuke Sato & Yasuhi, 2023. "Singlet fission as a polarized spin generator for dynamic nuclear polarization," Nature Communications, Nature, vol. 14(1), pages 1-12, December.

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