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The impact of sleep deprivation on food desire in the human brain

Author

Listed:
  • Stephanie M. Greer

    (Helen Wills Neuroscience Institute, University of California)

  • Andrea N. Goldstein

    (Helen Wills Neuroscience Institute, University of California)

  • Matthew P. Walker

    (Helen Wills Neuroscience Institute, University of California
    University of California)

Abstract

Epidemiological evidence supports a link between sleep loss and obesity. However, the detrimental impact of sleep deprivation on central brain mechanisms governing appetitive food desire remains unknown. Here we report that sleep deprivation significantly decreases activity in appetitive evaluation regions within the human frontal cortex and insular cortex during food desirability choices, combined with a converse amplification of activity within the amygdala. Moreover, this bi-directional change in the profile of brain activity is further associated with a significant increase in the desire for weight-gain promoting high-calorie foods following sleep deprivation, the extent of which is predicted by the subjective severity of sleep loss across participants. These findings provide an explanatory brain mechanism by which insufficient sleep may lead to the development/maintenance of obesity through diminished activity in higher-order cortical evaluation regions, combined with excess subcortical limbic responsivity, resulting in the selection of foods most capable of triggering weight-gain.

Suggested Citation

  • Stephanie M. Greer & Andrea N. Goldstein & Matthew P. Walker, 2013. "The impact of sleep deprivation on food desire in the human brain," Nature Communications, Nature, vol. 4(1), pages 1-7, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3259
    DOI: 10.1038/ncomms3259
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    Cited by:

    1. Gilberto M. Galindo-Aldana & Luis A. Padilla-López & Cynthia Torres-González & Ibza A. García-León & Joaquín A. Padilla-Bautista & Daniel N. Alvarez-Núñez, 2022. "Effects of Socio-Familial Behavior on Sleep Quality Predictive Risk Factors in Individuals under Social Isolation," IJERPH, MDPI, vol. 19(6), pages 1-12, March.
    2. Jara-Díaz, Sergio R. & Rosales-Salas, Jorge, 2020. "Time use: The role of sleep," Transportation Research Part A: Policy and Practice, Elsevier, vol. 136(C), pages 1-20.
    3. Osea Giuntella & Fabrizio Mazzonna, 2015. "If You Don’t Snooze You Lose Health and Gain Weight Evidence from a Regression Discontinuity Design," IdEP Economic Papers 1505, USI Università della Svizzera italiana.
    4. Emma C. Sullivan & Elizabeth J. Halstead & Jason G. Ellis & Dagmara Dimitriou, 2021. "Anxiety, Insomnia, and Napping Predict Poorer Sleep Quality in an Autistic Adult Population," IJERPH, MDPI, vol. 18(18), pages 1-15, September.
    5. Jonas Vinstrup & Markus D. Jakobsen & Lars L. Andersen, 2020. "Poor Sleep Is a Risk Factor for Low-Back Pain among Healthcare Workers: Prospective Cohort Study," IJERPH, MDPI, vol. 17(3), pages 1-8, February.
    6. Giuntella, Osea & Mazzonna, Fabrizio, 2016. "If You Don't Snooze You Lose: Evidence on Health and Weight," IZA Discussion Papers 9773, Institute of Labor Economics (IZA).
    7. Cailan Lindsay Feingold & Abbas Smiley, 2022. "Healthy Sleep Every Day Keeps the Doctor Away," IJERPH, MDPI, vol. 19(17), pages 1-35, August.
    8. Bingqian Zhu & Pamela Martyn‐Nemeth & Laurie Ruggiero & Chang G. Park & Yaqing Zhang & Cynthia Fritschi, 2019. "Associations between fatigue, sleep disturbance and eating style in adults with type 2 diabetes: A correlational study," Journal of Clinical Nursing, John Wiley & Sons, vol. 28(17-18), pages 3200-3209, September.

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