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Bio-responsive polymer hydrogels homeostatically regulate blood coagulation

Author

Listed:
  • Manfred F. Maitz

    (Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden)

  • Uwe Freudenberg

    (Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden)

  • Mikhail V. Tsurkan

    (Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden)

  • Marion Fischer

    (Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden)

  • Theresa Beyrich

    (Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden)

  • Carsten Werner

    (Max Bergmann Center of Biomaterials, Leibniz Institute of Polymer Research Dresden)

Abstract

Bio-responsive polymer architectures can empower medical therapies by engaging molecular feedback-response mechanisms resembling the homeostatic adaptation of living tissues to varying environmental constraints. Here we show that a blood coagulation-responsive hydrogel system can deliver heparin in amounts triggered by the environmental levels of thrombin, the key enzyme of the coagulation cascade, which—in turn—becomes inactivated due to released heparin. The bio-responsive hydrogel quantitatively quenches blood coagulation over several hours in the presence of pro-coagulant stimuli and during repeated incubation with fresh, non-anticoagulated blood. These features enable the introduced material to provide sustainable, autoregulated anticoagulation, addressing a key challenge of many medical therapies. Beyond that, the explored concept may facilitate the development of materials that allow the effective and controlled application of drugs and biomolecules.

Suggested Citation

  • Manfred F. Maitz & Uwe Freudenberg & Mikhail V. Tsurkan & Marion Fischer & Theresa Beyrich & Carsten Werner, 2013. "Bio-responsive polymer hydrogels homeostatically regulate blood coagulation," Nature Communications, Nature, vol. 4(1), pages 1-7, October.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms3168
    DOI: 10.1038/ncomms3168
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    Cited by:

    1. Wonjun Yim & Zhicheng Jin & Yu-Ci Chang & Carlos Brambila & Matthew N. Creyer & Chuxuan Ling & Tengyu He & Yi Li & Maurice Retout & William F. Penny & Jiajing Zhou & Jesse V. Jokerst, 2024. "Polyphenol-stabilized coacervates for enzyme-triggered drug delivery," Nature Communications, Nature, vol. 15(1), pages 1-11, December.

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