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Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans

Author

Listed:
  • Paul Brotherton

    (The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide
    Archaeogenetics Research Group, School of Applied Sciences, University of Huddersfield)

  • Wolfgang Haak

    (The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide)

  • Jennifer Templeton

    (The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide)

  • Guido Brandt

    (Institute of Anthropology, Colonel-Kleinmann Weg 2, Johannes Gutenberg University Mainz)

  • Julien Soubrier

    (The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide)

  • Christina Jane Adler

    (The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide
    Present address: Institute of Dental Research, Westmead Centre for Oral Health, The University of Sydney, Sydney, New South Wales 2145, Australia)

  • Stephen M. Richards

    (The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide)

  • Clio Der Sarkissian

    (The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide
    Present address: Centre for Geogenetics, Natural History Museum of Denmark, 1350 Copenhagen, Denmark)

  • Robert Ganslmeier

    (State Office for Heritage Management and Archaeology Saxony-Anhalt/State Museum for Prehistory Halle)

  • Susanne Friederich

    (State Office for Heritage Management and Archaeology Saxony-Anhalt/State Museum for Prehistory Halle)

  • Veit Dresely

    (State Office for Heritage Management and Archaeology Saxony-Anhalt/State Museum for Prehistory Halle)

  • Mannis van Oven

    (Erasmus MC, University Medical Centre Rotterdam)

  • Rosalie Kenyon

    (SA Pathology, SA Health)

  • Mark B. Van der Hoek

    (SA Pathology, SA Health)

  • Jonas Korlach

    (Pacific Biosciences)

  • Khai Luong

    (Pacific Biosciences)

  • Simon Y.W. Ho

    (School of Biological Sciences, The University of Sydney)

  • Lluis Quintana-Murci

    (Institut Pasteur, Unit of Evolutionary Genetics)

  • Doron M. Behar

    (Rambam Medical Centre)

  • Harald Meller

    (State Office for Heritage Management and Archaeology Saxony-Anhalt/State Museum for Prehistory Halle)

  • Kurt W. Alt

    (Institute of Anthropology, Colonel-Kleinmann Weg 2, Johannes Gutenberg University Mainz)

  • Alan Cooper

    (The Australian Centre for Ancient DNA, School of Earth and Environmental Sciences, University of Adelaide)

Abstract

Haplogroup H dominates present-day Western European mitochondrial DNA variability (>40%), yet was less common (~19%) among Early Neolithic farmers (~5450 BC) and virtually absent in Mesolithic hunter-gatherers. Here we investigate this major component of the maternal population history of modern Europeans and sequence 39 complete haplogroup H mitochondrial genomes from ancient human remains. We then compare this ‘real-time’ genetic data with cultural changes taking place between the Early Neolithic (~5450 BC) and Bronze Age (~2200 BC) in Central Europe. Our results reveal that the current diversity and distribution of haplogroup H were largely established by the Mid Neolithic (~4000 BC), but with substantial genetic contributions from subsequent pan-European cultures such as the Bell Beakers expanding out of Iberia in the Late Neolithic (~2800 BC). Dated haplogroup H genomes allow us to reconstruct the recent evolutionary history of haplogroup H and reveal a mutation rate 45% higher than current estimates for human mitochondria.

Suggested Citation

  • Paul Brotherton & Wolfgang Haak & Jennifer Templeton & Guido Brandt & Julien Soubrier & Christina Jane Adler & Stephen M. Richards & Clio Der Sarkissian & Robert Ganslmeier & Susanne Friederich & Veit, 2013. "Neolithic mitochondrial haplogroup H genomes and the genetic origins of Europeans," Nature Communications, Nature, vol. 4(1), pages 1-11, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2656
    DOI: 10.1038/ncomms2656
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    Cited by:

    1. Veronika Csákyová & Anna Szécsényi-Nagy & Aranka Csősz & Melinda Nagy & Gabriel Fusek & Péter Langó & Miroslav Bauer & Balázs Gusztáv Mende & Pavol Makovický & Mária Bauerová, 2016. "Maternal Genetic Composition of a Medieval Population from a Hungarian-Slavic Contact Zone in Central Europe," PLOS ONE, Public Library of Science, vol. 11(3), pages 1-15, March.
    2. Daniel Gómez-Sánchez & Iñigo Olalde & Federica Pierini & Laura Matas-Lalueza & Elena Gigli & Martina Lari & Sergi Civit & Marina Lozano & Josep Maria Vergès & David Caramelli & Oscar Ramírez & Carles , 2014. "Mitochondrial DNA from El Mirador Cave (Atapuerca, Spain) Reveals the Heterogeneity of Chalcolithic Populations," PLOS ONE, Public Library of Science, vol. 9(8), pages 1-8, August.

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