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Telomeres shorten at equivalent rates in somatic tissues of adults

Author

Listed:
  • Lily Daniali

    (University of Medicine and Dentistry of New Jersey, New Jersey Medical School)

  • Athanase Benetos

    (Geriatric Service, Nancy University Hospital
    Inserm U961, Faculty of Medicine, Universite de Lorraine)

  • Ezra Susser

    (Mailman School of Public Health, Columbia University
    New York State Psychiatric Institute)

  • Jeremy D. Kark

    (Epidemiology Unit, The Hebrew University–Hadassah School of Public Health and Community Medicine, Ein Kerem, Jerusalem 91120, Israel)

  • Carlos Labat

    (Geriatric Service, Nancy University Hospital
    Inserm U961, Faculty of Medicine, Universite de Lorraine)

  • Masayuki Kimura

    (The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School)

  • Kunj K. Desai

    (University of Medicine and Dentistry of New Jersey, New Jersey Medical School)

  • Mark Granick

    (University of Medicine and Dentistry of New Jersey, New Jersey Medical School)

  • Abraham Aviv

    (The Center of Human Development and Aging, University of Medicine and Dentistry of New Jersey, New Jersey Medical School)

Abstract

Telomere shortening in somatic tissues largely reflects stem cell replication. Previous human studies of telomere attrition were predominantly conducted on leukocytes. However, findings in leukocytes cannot be generalized to other tissues. Here we measure telomere length in leukocytes, skeletal muscle, skin and subcutaneous fat of 87 adults (aged 19–77 years). Telomeres are longest in muscle and shortest in leukocytes, yet are strongly correlated between tissues. Notably, the rates of telomere shortening are similar in the four tissues. We infer from these findings that differences in telomere length between proliferative (blood and skin) and minimally proliferative tissues (muscle and fat) are established during early life, and that in adulthood, stem cells of the four tissues replicate at a similar rate.

Suggested Citation

  • Lily Daniali & Athanase Benetos & Ezra Susser & Jeremy D. Kark & Carlos Labat & Masayuki Kimura & Kunj K. Desai & Mark Granick & Abraham Aviv, 2013. "Telomeres shorten at equivalent rates in somatic tissues of adults," Nature Communications, Nature, vol. 4(1), pages 1-7, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2602
    DOI: 10.1038/ncomms2602
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    Cited by:

    1. Leena Ala-Mursula & Jessica L Buxton & Ellen Ek & Markku Koiranen & Anja Taanila & Alexandra I F Blakemore & Marjo-Riitta Järvelin, 2013. "Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-8, November.
    2. Whisman, Mark A. & Robustelli, Briana L. & Sbarra, David A., 2016. "Marital disruption is associated with shorter salivary telomere length in a probability sample of older adults," Social Science & Medicine, Elsevier, vol. 157(C), pages 60-67.
    3. Ayodeji Adegunsoye & Chad A. Newton & Justin M. Oldham & Brett Ley & Cathryn T. Lee & Angela L. Linderholm & Jonathan H. Chung & Nicole Garcia & Da Zhang & Rekha Vij & Robert Guzy & Renea Jablonski & , 2023. "Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    4. Monika A Izano & Lara J Cushing & Jue Lin & Stephanie M Eick & Dana E Goin & Elissa Epel & Tracey J Woodruff & Rachel Morello-Frosch, 2020. "The association of maternal psychosocial stress with newborn telomere length," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-11, December.
    5. Lilit Nersisyan & Arsen Arakelyan, 2015. "Computel: Computation of Mean Telomere Length from Whole-Genome Next-Generation Sequencing Data," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-14, April.

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