IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v14y2023i1d10.1038_s41467-023-37193-6.html
   My bibliography  Save this article

Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts

Author

Listed:
  • Ayodeji Adegunsoye

    (The University of Chicago
    The University of Chicago)

  • Chad A. Newton

    (University of Texas Southwestern)

  • Justin M. Oldham

    (University of California, Davis)

  • Brett Ley

    (University of California)

  • Cathryn T. Lee

    (The University of Chicago)

  • Angela L. Linderholm

    (University of California, Davis)

  • Jonathan H. Chung

    (The University of Chicago)

  • Nicole Garcia

    (The University of Chicago)

  • Da Zhang

    (Columbia University Medical Center)

  • Rekha Vij

    (The University of Chicago)

  • Robert Guzy

    (The University of Chicago)

  • Renea Jablonski

    (The University of Chicago)

  • Remzi Bag

    (The University of Chicago)

  • Rebecca S. Voogt

    (The University of Chicago)

  • Shwu-Fan Ma

    (University of Virginia)

  • Anne I. Sperling

    (The University of Chicago)

  • Ganesh Raghu

    (University of Washington Medical Center)

  • Fernando J. Martinez

    (Weill Cornell Medicine)

  • Mary E. Strek

    (The University of Chicago)

  • Paul J. Wolters

    (University of California)

  • Christine Kim Garcia

    (Columbia University Medical Center)

  • Brandon L. Pierce

    (The University of Chicago
    The University of Chicago)

  • Imre Noth

    (University of Virginia)

Abstract

Pulmonary fibrosis (PF) is characterized by profound scarring and poor survival. We investigated the association of leukocyte telomere length (LTL) with chronological age and mortality across racially diverse PF cohorts. LTL measurements among participants with PF stratified by race/ethnicity were assessed in relation to age and all-cause mortality, and compared to controls. Generalized linear models were used to evaluate the age-LTL relationship, Cox proportional hazards models were used for hazard ratio estimation, and the Cochran–Armitage test was used to assess quartiles of LTL. Standardized LTL shortened with increasing chronological age; this association in controls was strengthened in PF (R = −0.28; P

Suggested Citation

  • Ayodeji Adegunsoye & Chad A. Newton & Justin M. Oldham & Brett Ley & Cathryn T. Lee & Angela L. Linderholm & Jonathan H. Chung & Nicole Garcia & Da Zhang & Rekha Vij & Robert Guzy & Renea Jablonski & , 2023. "Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37193-6
    DOI: 10.1038/s41467-023-37193-6
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-023-37193-6
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-023-37193-6?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Lily Daniali & Athanase Benetos & Ezra Susser & Jeremy D. Kark & Carlos Labat & Masayuki Kimura & Kunj K. Desai & Mark Granick & Abraham Aviv, 2013. "Telomeres shorten at equivalent rates in somatic tissues of adults," Nature Communications, Nature, vol. 4(1), pages 1-7, June.
    2. Lily Daniali & Athanase Benetos & Ezra Susser & Jeremy D. Kark & Carlos Labat & Masayuki Kimura & Kunj K. Desai & Mark Granick & Abraham Aviv, 2013. "Correction: Corrigendum: Telomeres shorten at equivalent rates in somatic tissues of adults," Nature Communications, Nature, vol. 4(1), pages 1-1, October.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Monika A Izano & Lara J Cushing & Jue Lin & Stephanie M Eick & Dana E Goin & Elissa Epel & Tracey J Woodruff & Rachel Morello-Frosch, 2020. "The association of maternal psychosocial stress with newborn telomere length," PLOS ONE, Public Library of Science, vol. 15(12), pages 1-11, December.
    2. Leena Ala-Mursula & Jessica L Buxton & Ellen Ek & Markku Koiranen & Anja Taanila & Alexandra I F Blakemore & Marjo-Riitta Järvelin, 2013. "Long-Term Unemployment Is Associated with Short Telomeres in 31-Year-Old Men: An Observational Study in the Northern Finland Birth Cohort 1966," PLOS ONE, Public Library of Science, vol. 8(11), pages 1-8, November.
    3. Whisman, Mark A. & Robustelli, Briana L. & Sbarra, David A., 2016. "Marital disruption is associated with shorter salivary telomere length in a probability sample of older adults," Social Science & Medicine, Elsevier, vol. 157(C), pages 60-67.
    4. Lilit Nersisyan & Arsen Arakelyan, 2015. "Computel: Computation of Mean Telomere Length from Whole-Genome Next-Generation Sequencing Data," PLOS ONE, Public Library of Science, vol. 10(4), pages 1-14, April.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37193-6. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.