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Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts

Author

Listed:
  • Ayodeji Adegunsoye

    (The University of Chicago
    The University of Chicago)

  • Chad A. Newton

    (University of Texas Southwestern)

  • Justin M. Oldham

    (University of California, Davis)

  • Brett Ley

    (University of California)

  • Cathryn T. Lee

    (The University of Chicago)

  • Angela L. Linderholm

    (University of California, Davis)

  • Jonathan H. Chung

    (The University of Chicago)

  • Nicole Garcia

    (The University of Chicago)

  • Da Zhang

    (Columbia University Medical Center)

  • Rekha Vij

    (The University of Chicago)

  • Robert Guzy

    (The University of Chicago)

  • Renea Jablonski

    (The University of Chicago)

  • Remzi Bag

    (The University of Chicago)

  • Rebecca S. Voogt

    (The University of Chicago)

  • Shwu-Fan Ma

    (University of Virginia)

  • Anne I. Sperling

    (The University of Chicago)

  • Ganesh Raghu

    (University of Washington Medical Center)

  • Fernando J. Martinez

    (Weill Cornell Medicine)

  • Mary E. Strek

    (The University of Chicago)

  • Paul J. Wolters

    (University of California)

  • Christine Kim Garcia

    (Columbia University Medical Center)

  • Brandon L. Pierce

    (The University of Chicago
    The University of Chicago)

  • Imre Noth

    (University of Virginia)

Abstract

Pulmonary fibrosis (PF) is characterized by profound scarring and poor survival. We investigated the association of leukocyte telomere length (LTL) with chronological age and mortality across racially diverse PF cohorts. LTL measurements among participants with PF stratified by race/ethnicity were assessed in relation to age and all-cause mortality, and compared to controls. Generalized linear models were used to evaluate the age-LTL relationship, Cox proportional hazards models were used for hazard ratio estimation, and the Cochran–Armitage test was used to assess quartiles of LTL. Standardized LTL shortened with increasing chronological age; this association in controls was strengthened in PF (R = −0.28; P

Suggested Citation

  • Ayodeji Adegunsoye & Chad A. Newton & Justin M. Oldham & Brett Ley & Cathryn T. Lee & Angela L. Linderholm & Jonathan H. Chung & Nicole Garcia & Da Zhang & Rekha Vij & Robert Guzy & Renea Jablonski & , 2023. "Telomere length associates with chronological age and mortality across racially diverse pulmonary fibrosis cohorts," Nature Communications, Nature, vol. 14(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:14:y:2023:i:1:d:10.1038_s41467-023-37193-6
    DOI: 10.1038/s41467-023-37193-6
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    References listed on IDEAS

    as
    1. Lily Daniali & Athanase Benetos & Ezra Susser & Jeremy D. Kark & Carlos Labat & Masayuki Kimura & Kunj K. Desai & Mark Granick & Abraham Aviv, 2013. "Telomeres shorten at equivalent rates in somatic tissues of adults," Nature Communications, Nature, vol. 4(1), pages 1-7, June.
    2. Lily Daniali & Athanase Benetos & Ezra Susser & Jeremy D. Kark & Carlos Labat & Masayuki Kimura & Kunj K. Desai & Mark Granick & Abraham Aviv, 2013. "Correction: Corrigendum: Telomeres shorten at equivalent rates in somatic tissues of adults," Nature Communications, Nature, vol. 4(1), pages 1-1, October.
    Full references (including those not matched with items on IDEAS)

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