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Magnetic spin imaging under ambient conditions with sub-cellular resolution

Author

Listed:
  • S. Steinert

    (3rd Institute of Physics and Research Center SCOPE, University Stuttgart)

  • F. Ziem

    (3rd Institute of Physics and Research Center SCOPE, University Stuttgart)

  • L. T. Hall

    (Centre for Quantum Computation and Communication Technology, School of Physics, University of Melbourne)

  • A. Zappe

    (3rd Institute of Physics and Research Center SCOPE, University Stuttgart)

  • M. Schweikert

    (Biologisches Institut, University Stuttgart)

  • N. Götz

    (3rd Institute of Physics and Research Center SCOPE, University Stuttgart)

  • A. Aird

    (3rd Institute of Physics and Research Center SCOPE, University Stuttgart)

  • G. Balasubramanian

    (Research Group Nanoscale Spin Imaging, Max-Planck Institute of Biophysical Chemistry and Center for Nanoscale Microscopy and Molecular Physiology of the Brain (CNMPB))

  • L. Hollenberg

    (Centre for Quantum Computation and Communication Technology, School of Physics, University of Melbourne)

  • J. Wrachtrup

    (3rd Institute of Physics and Research Center SCOPE, University Stuttgart)

Abstract

The detection of small numbers of magnetic spins is a significant challenge in the life, physical and chemical sciences, especially when room temperature operation is required. Here we show that a proximal nitrogen-vacancy spin ensemble serves as a high precision sensing and imaging array. Monitoring its longitudinal relaxation enables sensing of freely diffusing, unperturbed magnetic ions and molecules in a microfluidic device without applying external magnetic fields. Multiplexed charge-coupled device acquisition and an optimized detection scheme permits direct spin noise imaging of magnetically labelled cellular structures under ambient conditions. Within 20 s we achieve spatial resolutions below 500 nm and experimental sensitivities down to 1,000 statistically polarized spins, of which only 32 ions contribute to a net magnetization. The results mark a major step towards versatile sub-cellular magnetic imaging and real-time spin sensing under physiological conditions providing a minimally invasive tool to monitor ion channels or haemoglobin trafficking inside live cells.

Suggested Citation

  • S. Steinert & F. Ziem & L. T. Hall & A. Zappe & M. Schweikert & N. Götz & A. Aird & G. Balasubramanian & L. Hollenberg & J. Wrachtrup, 2013. "Magnetic spin imaging under ambient conditions with sub-cellular resolution," Nature Communications, Nature, vol. 4(1), pages 1-6, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2588
    DOI: 10.1038/ncomms2588
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    Cited by:

    1. Zhuoyang Qin & Zhecheng Wang & Fei Kong & Jia Su & Zhehua Huang & Pengju Zhao & Sanyou Chen & Qi Zhang & Fazhan Shi & Jiangfeng Du, 2023. "In situ electron paramagnetic resonance spectroscopy using single nanodiamond sensors," Nature Communications, Nature, vol. 14(1), pages 1-8, December.

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