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Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans

Author

Listed:
  • Sanne P. Smeekens

    (Radboud University Nijmegen Medical Centre
    Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) (463))

  • Aylwin Ng

    (The Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center
    Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School)

  • Vinod Kumar

    (University Medical Centre Groningen)

  • Melissa D. Johnson

    (Duke University Medical Center
    Campbell University School of Pharmacy)

  • Theo S. Plantinga

    (Radboud University Nijmegen Medical Centre
    Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) (463))

  • Cleo van Diemen

    (University Medical Centre Groningen)

  • Peer Arts

    (Radboud University Nijmegen Medical Center)

  • Eugène T. P. Verwiel

    (Radboud University Nijmegen Medical Center)

  • Mark S. Gresnigt

    (Radboud University Nijmegen Medical Centre
    Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) (463))

  • Karin Fransen

    (University Medical Centre Groningen)

  • Suzanne van Sommeren

    (University Medical Centre Groningen)

  • Marije Oosting

    (Radboud University Nijmegen Medical Centre
    Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) (463))

  • Shih-Chin Cheng

    (Radboud University Nijmegen Medical Centre
    Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) (463))

  • Leo A. B. Joosten

    (Radboud University Nijmegen Medical Centre
    Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) (463))

  • Alexander Hoischen

    (Radboud University Nijmegen Medical Center)

  • Bart-Jan Kullberg

    (Radboud University Nijmegen Medical Centre
    Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) (463))

  • William K. Scott

    (University of Miami, Miller School of Medicine)

  • John R. Perfect

    (Duke University Medical Center
    Campbell University School of Pharmacy)

  • Jos W. M. van der Meer

    (Radboud University Nijmegen Medical Centre
    Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) (463))

  • Cisca Wijmenga

    (University Medical Centre Groningen)

  • Mihai G. Netea

    (Radboud University Nijmegen Medical Centre
    Nijmegen Institute for Infection, Inflammation, and Immunity (N4i) (463))

  • Ramnik J. Xavier

    (The Broad Institute of Massachusetts Institute of Technology and Harvard University, 7 Cambridge Center
    Center for Computational and Integrative Biology and Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School)

Abstract

Candida albicans is the most common human fungal pathogen causing mucosal and systemic infections. However, human antifungal immunity remains poorly defined. Here by integrating transcriptional analysis and functional genomics, we identified Candida-specific host defence mechanisms in humans. Candida induced significant expression of genes from the type I interferon pathway in human peripheral blood mononuclear cells. This unexpectedly prominent role of type I interferon pathway in anti-Candida host defence was supported by additional evidence. Polymorphisms in type I interferon genes modulated Candida-induced cytokine production and were correlated with susceptibility to systemic candidiasis. In in vitro experiments, type I interferons skewed Candida-induced inflammation from a Th17 response towards a Th1 response. Patients with chronic mucocutaneous candidiasis displayed defective expression of genes in the type I interferon pathway. These findings indicate that the type I interferon pathway is a main signature of Candida-induced inflammation and has a crucial role in anti-Candida host defence in humans.

Suggested Citation

  • Sanne P. Smeekens & Aylwin Ng & Vinod Kumar & Melissa D. Johnson & Theo S. Plantinga & Cleo van Diemen & Peer Arts & Eugène T. P. Verwiel & Mark S. Gresnigt & Karin Fransen & Suzanne van Sommeren & Ma, 2013. "Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans," Nature Communications, Nature, vol. 4(1), pages 1-10, June.
    • Handle: RePEc:nat:natcom:v:4:y:2013:i:1:d:10.1038_ncomms2343
    DOI: 10.1038/ncomms2343
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    Cited by:

    1. Cristina Molina-López & Laura Hurtado-Navarro & Carlos J. García & Diego Angosto-Bazarra & Fernando Vallejo & Ana Tapia-Abellán & Joana R. Marques-Soares & Carmen Vargas & Segundo Bujan-Rivas & Franci, 2024. "Pathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production," Nature Communications, Nature, vol. 15(1), pages 1-21, December.
    2. Otavio Cabral-Marques & Gilad Halpert & Lena F. Schimke & Yuri Ostrinski & Aristo Vojdani & Gabriela Crispim Baiocchi & Paula Paccielli Freire & Igor Salerno Filgueiras & Israel Zyskind & Miriam T. La, 2022. "Autoantibodies targeting GPCRs and RAS-related molecules associate with COVID-19 severity," Nature Communications, Nature, vol. 13(1), pages 1-12, December.
    3. Roy Oelen & Dylan H. Vries & Harm Brugge & M. Grace Gordon & Martijn Vochteloo & Chun J. Ye & Harm-Jan Westra & Lude Franke & Monique G. P. Wijst, 2022. "Single-cell RNA-sequencing of peripheral blood mononuclear cells reveals widespread, context-specific gene expression regulation upon pathogenic exposure," Nature Communications, Nature, vol. 13(1), pages 1-15, December.

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