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The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27–CD70 interactions

Author

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  • Sonia Feau

    (Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology)

  • Zacarias Garcia

    (Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology
    Present address: Institut Pasteur, Unité 'Dynamique des Réponses Immunes', INSERM U668, 25 rue du Docteur Roux, 75724 PARIS Cedex 15, France.)

  • Ramon Arens

    (Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology
    Present address: Department of Immunohematology and Blood Transfusion, Leiden University Medical Center, 2333ZA, The Netherlands.)

  • Hideo Yagita

    (Juntendo University School of Medicine, 2-1-1 Hongo, Bunkyo-ku, Tokyo 113-8421, Japan.)

  • Jannie Borst

    (The Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, The Netherlands.)

  • Stephen P. Schoenberger

    (Laboratory of Cellular Immunology, La Jolla Institute for Allergy and Immunology)

Abstract

CD8+ cytotoxic T lymphocytes are critical components of immunity against infectious pathogens, tumours, and in the case of pathogenic autoimmunity, normal self tissues. CD4+ T (TH) cells provide 'help' to CD8+ cytotoxic T lymphocytes during priming by first activating antigen-presenting cells via CD40–CD40L interactions. Here we show that, after immunization with either a noninflammatory, nonreplicating antigen or an overtly inflammatory replicating antigen, CD8+ cytotoxic T lymphocytes prevented from receiving a signal through CD27 during priming subsequently exhibit a specific defect in their capacity for secondary expansion that can be rescued by the absence of TRAIL. Thus, the 'help message' is transmitted to CD8+ T cells via CD70–CD27 signals, enabling them to undergo secondary expansion and avoid TRAIL-mediated apoptosis on re-stimulation. These findings complete our understanding of the cellular interactions through which TH is provided to CD8+ cytotoxic T lymphocytes during priming.

Suggested Citation

  • Sonia Feau & Zacarias Garcia & Ramon Arens & Hideo Yagita & Jannie Borst & Stephen P. Schoenberger, 2012. "The CD4+ T-cell help signal is transmitted from APC to CD8+ T-cells via CD27–CD70 interactions," Nature Communications, Nature, vol. 3(1), pages 1-9, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1948
    DOI: 10.1038/ncomms1948
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    Cited by:

    1. Xin Lei & Indu Khatri & Tom Wit & Iris Rink & Marja Nieuwland & Ron Kerkhoven & Hans Eenennaam & Chong Sun & Abhishek D. Garg & Jannie Borst & Yanling Xiao, 2023. "CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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