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Microscopic magnetic stimulation of neural tissue

Author

Listed:
  • Giorgio Bonmassar

    (Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital)

  • Seung Woo Lee

    (Center for Innovative Visual Rehabilitation, Boston VA Healthcare System
    Massachusetts General Hospital, Harvard Medical School)

  • Daniel K. Freeman

    (Center for Innovative Visual Rehabilitation, Boston VA Healthcare System
    Massachusetts General Hospital, Harvard Medical School)

  • Miloslav Polasek

    (Athinoula A. Martinos Center for Biomedical Imaging, Harvard Medical School, Massachusetts General Hospital)

  • Shelley I. Fried

    (Center for Innovative Visual Rehabilitation, Boston VA Healthcare System
    Massachusetts General Hospital, Harvard Medical School)

  • John T. Gale

    (Cleveland Clinic, Neurological Institute
    School of Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University)

Abstract

Electrical stimulation is currently used to treat a wide range of cardiovascular, sensory and neurological diseases. Despite its success, there are significant limitations to its application, including incompatibility with magnetic resonance imaging, limited control of electric fields and decreased performance associated with tissue inflammation. Magnetic stimulation overcomes these limitations but existing devices (that is, transcranial magnetic stimulation) are large, reducing their translation to chronic applications. In addition, existing devices are not effective for deeper, sub-cortical targets. Here we demonstrate that sub-millimeter coils can activate neuronal tissue. Interestingly, the results of both modelling and physiological experiments suggest that different spatial orientations of the coils relative to the neuronal tissue can be used to generate specific neural responses. These results raise the possibility that micro-magnetic stimulation coils, small enough to be implanted within the brain parenchyma, may prove to be an effective alternative to existing stimulation devices.

Suggested Citation

  • Giorgio Bonmassar & Seung Woo Lee & Daniel K. Freeman & Miloslav Polasek & Shelley I. Fried & John T. Gale, 2012. "Microscopic magnetic stimulation of neural tissue," Nature Communications, Nature, vol. 3(1), pages 1-10, January.
    • Handle: RePEc:nat:natcom:v:3:y:2012:i:1:d:10.1038_ncomms1914
    DOI: 10.1038/ncomms1914
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    Cited by:

    1. Jianqiang Zhang & Xuejiao Wang & Zhaoyue Wang & Shangfa Pan & Bo Yi & Liqing Ai & Jun Gao & Frieder Mugele & Xi Yao, 2021. "Wetting ridge assisted programmed magnetic actuation of droplets on ferrofluid-infused surface," Nature Communications, Nature, vol. 12(1), pages 1-8, December.

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