IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v2y2011i1d10.1038_ncomms1316.html
   My bibliography  Save this article

Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus

Author

Listed:
  • Masao Doi

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Atsushi Ishida

    (Graduate School of Medicine, Kobe University)

  • Akiko Miyake

    (Graduate School of Medicine, Kobe University)

  • Miho Sato

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Rie Komatsu

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Fumiyoshi Yamazaki

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Ikuo Kimura

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Soken Tsuchiya

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Hiroshi Kori

    (Ochadai Academic Production, Ochanomizu University
    PRESTO, Japan Science and Technology Agency)

  • Kazuyuki Seo

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Yoshiaki Yamaguchi

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Masahiro Matsuo

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Jean-Michel Fustin

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Rina Tanaka

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Yasuko Santo

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Hiroyuki Yamada

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Yukari Takahashi

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Michihiro Araki

    (Education Unit for Global Leaders, Kyoto University)

  • Kazuki Nakao

    (Laboratory for Animal Resources and Genetic Engineering, Riken Center for Developmental Biology)

  • Shinichi Aizawa

    (Laboratory for Animal Resources and Genetic Engineering, Riken Center for Developmental Biology)

  • Masaki Kobayashi

    (Tohoku Institute of Technology)

  • Karl Obrietan

    (The Ohio State University)

  • Gozoh Tsujimoto

    (Graduate School of Pharmaceutical Sciences, Kyoto University)

  • Hitoshi Okamura

    (Graduate School of Pharmaceutical Sciences, Kyoto University
    Graduate School of Medicine, Kobe University)

Abstract

Synchronous oscillations of thousands of cellular clocks in the suprachiasmatic nucleus (SCN), the circadian centre, are coordinated by precisely timed cell–cell communication, the principle of which is largely unknown. Here we show that the amount of RGS16 (regulator of G protein signalling 16), a protein known to inactivate Gαi, increases at a selective circadian time to allow time-dependent activation of intracellular cyclic AMP signalling in the SCN. Gene ablation of Rgs16 leads to the loss of circadian production of cAMP and as a result lengthens circadian period of behavioural rhythm. The temporally precise regulation of the cAMP signal by clock-controlled RGS16 is needed for the dorsomedial SCN to maintain a normal phase-relationship to the ventrolateral SCN. Thus, RGS16-dependent temporal regulation of intracellular G protein signalling coordinates the intercellular synchrony of SCN pacemaker neurons and thereby defines the 24 h rhythm in behaviour.

Suggested Citation

  • Masao Doi & Atsushi Ishida & Akiko Miyake & Miho Sato & Rie Komatsu & Fumiyoshi Yamazaki & Ikuo Kimura & Soken Tsuchiya & Hiroshi Kori & Kazuyuki Seo & Yoshiaki Yamaguchi & Masahiro Matsuo & Jean-Mich, 2011. "Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus," Nature Communications, Nature, vol. 2(1), pages 1-9, September.
  • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1316
    DOI: 10.1038/ncomms1316
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/ncomms1316
    File Function: Abstract
    Download Restriction: no

    File URL: https://libkey.io/10.1038/ncomms1316?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Šimonka, Vito & Fras, Maja & Gosak, Marko, 2015. "Stochastic simulation of the circadian rhythmicity in the SCN neuronal network," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 424(C), pages 1-10.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1316. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.