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Recovery from chronic monocular deprivation following reactivation of thalamocortical plasticity by dark exposure

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  • Karen L. Montey

    (University of Maryland)

  • Elizabeth M. Quinlan

    (University of Maryland
    Neuroscience and Cognitive Sciences Program, University of Maryland)

Abstract

Chronic monocular deprivation induces severe amblyopia that is resistant to spontaneous reversal. However, dark exposure initiated in adulthood reactivates synaptic plasticity in the visual cortex and promotes recovery from chronic monocular deprivation in Long Evans rats. Here we show that chronic monocular deprivation induces a significant decrease in the density of dendritic spines on principal neurons throughout the deprived visual cortex. Nevertheless, dark exposure followed by reverse deprivation promotes the recovery of dendritic spine density of neurons in all laminae. Importantly, the ocular dominance of neurons in thalamo-recipient laminae of the cortex, and the amplitude of the thalamocortical visually evoked potential recover following dark exposure and reverse deprivation. Thus, dark exposure reactivates widespread synaptic plasticity in the adult visual cortex, including thalamocortical synapses, during the recovery from chronic monocular deprivation.

Suggested Citation

  • Karen L. Montey & Elizabeth M. Quinlan, 2011. "Recovery from chronic monocular deprivation following reactivation of thalamocortical plasticity by dark exposure," Nature Communications, Nature, vol. 2(1), pages 1-8, September.
    • Handle: RePEc:nat:natcom:v:2:y:2011:i:1:d:10.1038_ncomms1312
    DOI: 10.1038/ncomms1312
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    Cited by:

    1. Bryce D. Grier & Samuel Parkins & Jarra Omar & Hey-Kyoung Lee, 2023. "Selective plasticity of fast and slow excitatory synapses on somatostatin interneurons in adult visual cortex," Nature Communications, Nature, vol. 14(1), pages 1-14, December.

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