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The pathways of secretory cargo export at the endoplasmic reticulum

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  • Vivek Malhotra

    (The Barcelona Institute for Science and Technology)

Abstract

Palade’s original model proposed that secretory cargo is transported between stable compartments via vesicles. However, recent findings challenge this view, suggesting that secretory pathway compartments are dynamic, with cargo itself dictating whether transfer occurs via vesicles or through the continuity and maturation of compartmental structures. At the heart of this process is TANGO1, a key component of a molecular machine that works in concert with COPII proteins to construct export routes tailored to the size and quantity of secretory cargo.

Suggested Citation

  • Vivek Malhotra, 2025. "The pathways of secretory cargo export at the endoplasmic reticulum," Nature Communications, Nature, vol. 16(1), pages 1-5, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57408-2
    DOI: 10.1038/s41467-025-57408-2
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    References listed on IDEAS

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    1. Frederic Bard & Laetitia Casano & Arrate Mallabiabarrena & Erin Wallace & Kota Saito & Hitoshi Kitayama & Gianni Guizzunti & Yue Hu & Franz Wendler & Ramanuj DasGupta & Norbert Perrimon & Vivek Malhot, 2006. "Functional genomics reveals genes involved in protein secretion and Golgi organization," Nature, Nature, vol. 439(7076), pages 604-607, February.
    2. Kazuo Kurokawa & Michiyo Okamoto & Akihiko Nakano, 2014. "Contact of cis-Golgi with ER exit sites executes cargo capture and delivery from the ER," Nature Communications, Nature, vol. 5(1), pages 1-7, May.
    3. Oliver Arnolds & Raphael Stoll, 2023. "Characterization of a fold in TANGO1 evolved from SH3 domains for the export of bulky cargos," Nature Communications, Nature, vol. 14(1), pages 1-12, December.
    4. Ishier Raote & Ann-Helen Rosendahl & Hanna-Maria Häkkinen & Carina Vibe & Ismail Küçükaylak & Mugdha Sawant & Lena Keufgens & Pia Frommelt & Kai Halwas & Katrina Broadbent & Marina Cunquero & Gustavo , 2024. "TANGO1 inhibitors reduce collagen secretion and limit tissue scarring," Nature Communications, Nature, vol. 15(1), pages 1-12, December.
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