IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-57146-5.html
   My bibliography  Save this article

Drop-shaped microgrooves guide unidirectional cell migration for enhanced endothelialization

Author

Listed:
  • Xing-wang Wang

    (Zhejiang University)

  • Cheng-qiang Ye

    (Zhejiang University)

  • Qian Tang

    (Zhejiang University
    Engineering Research Center for Cardiovascular Innovative Devices of Zhejiang Province)

  • Hong-mei Yu

    (Zhejiang University)

  • Jing Wang

    (Zhejiang University
    The Second Affiliated Hospital Zhejiang University School of Medicine)

  • Guo-sheng Fu

    (Zhejiang University
    Engineering Research Center for Cardiovascular Innovative Devices of Zhejiang Province)

  • Ke-feng Ren

    (Zhejiang University
    Zhejiang University
    Engineering Research Center for Cardiovascular Innovative Devices of Zhejiang Province)

  • Lu Yu

    (Zhejiang University
    Engineering Research Center for Cardiovascular Innovative Devices of Zhejiang Province)

  • Jian Ji

    (Zhejiang University
    The Second Affiliated Hospital Zhejiang University School of Medicine)

Abstract

Atrial fibrillation (AF) significantly increases the risk of ischemic stroke, and in non-valvular AF, 90% of stroke-causing thrombi arise from the left atrial appendage (LAA). Percutaneous LAA occlusion using an occluder is a crucial clinical intervention. However, occluder materials could provoke thrombi, termed device-related thrombosis (DRT), leading to treatment failure. Rapid endothelialization is essential to address the DRT but the occluder’s large surface area and irregular cell migration on the surface impede this process. Here, we report a continuous drop-shaped microgroove, which has a drop-shaped unit structure similar to endothelial cells. The microgrooves polarize the cytoskeleton, guiding cell unidirectional migration within the grooves, and increase cell migration efficiency. We show that drop-shaped microgrooves accelerate wound healing in a rat model, and that occluder discs with drop-shaped microgrooves promote endothelialization in a canine model. Together, our results show that integrating microgrooves with medical devices is a promising approach for addressing DRT.

Suggested Citation

  • Xing-wang Wang & Cheng-qiang Ye & Qian Tang & Hong-mei Yu & Jing Wang & Guo-sheng Fu & Ke-feng Ren & Lu Yu & Jian Ji, 2025. "Drop-shaped microgrooves guide unidirectional cell migration for enhanced endothelialization," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57146-5
    DOI: 10.1038/s41467-025-57146-5
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-57146-5
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-57146-5?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Claire Leclech & David Gonzalez-Rodriguez & Aurélien Villedieu & Thévy Lok & Anne-Marie Déplanche & Abdul I. Barakat, 2022. "Topography-induced large-scale antiparallel collective migration in vascular endothelium," Nature Communications, Nature, vol. 13(1), pages 1-11, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.

      More about this item

      Statistics

      Access and download statistics

      Corrections

      All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-57146-5. See general information about how to correct material in RePEc.

      If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

      If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

      If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

      For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

      Please note that corrections may take a couple of weeks to filter through the various RePEc services.

      IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.