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An atlas of metabolites driving chemotaxis in prokaryotes

Author

Listed:
  • Maéva Brunet

    (University of Technology Sydney)

  • Shady A. Amin

    (New York University Abu Dhabi)

  • Iurii Bodachivskyi

    (V.P. Kukhar Institute of Bioorganic Chemistry and Petrochemistry of the NAS of Ukraine)

  • Unnikrishnan Kuzhiumparambil

    (University of Technology Sydney)

  • Justin R. Seymour

    (University of Technology Sydney)

  • Jean-Baptiste Raina

    (University of Technology Sydney)

Abstract

Chemicals inducing chemotaxis have been characterised for over 60 years across hundreds of publications. Without any synthesis of these scattered results, our current understanding of the molecules affecting prokaryotic behaviours is fragmented. Here, we examined 341 publications to assemble a comprehensive database of prokaryotic chemoeffectors, compiling the effect (attractant, repellent or neutral) of 926 chemicals previously tested and the chemotactic behaviour of 394 strains. Our analysis reveals that (i) not all chemical classes trigger chemotaxis equally, in particular, amino acids and benzenoids are much stronger attractants than carbohydrates; (ii) over one-quarter of attractants tested are not used for growth but solely act as chemotactic signals; (iii) the prokaryote’s origin matters, as terrestrial strains respond to 50% more chemicals than those originating from human or marine biomes; (iv) repellents affect cell behaviour at concentrations 10-fold higher than attractants; (v) the effect of large molecules and the behaviour of bacteria other than Proteobacteria have been largely overlooked. Taken together, our findings provide a unifying view of the chemical characteristics that affect prokaryotic behaviours globally.

Suggested Citation

  • Maéva Brunet & Shady A. Amin & Iurii Bodachivskyi & Unnikrishnan Kuzhiumparambil & Justin R. Seymour & Jean-Baptiste Raina, 2025. "An atlas of metabolites driving chemotaxis in prokaryotes," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
  • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-56410-y
    DOI: 10.1038/s41467-025-56410-y
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    References listed on IDEAS

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    1. Leanid Laganenka & Remy Colin & Victor Sourjik, 2016. "Correction: Corrigendum: Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli," Nature Communications, Nature, vol. 7(1), pages 1-1, December.
    2. Leanid Laganenka & Remy Colin & Victor Sourjik, 2016. "Chemotaxis towards autoinducer 2 mediates autoaggregation in Escherichia coli," Nature Communications, Nature, vol. 7(1), pages 1-11, December.
    3. Jean-Baptiste Raina & Bennett S. Lambert & Donovan H. Parks & Christian Rinke & Nachshon Siboni & Anna Bramucci & Martin Ostrowski & Brandon Signal & Adrian Lutz & Himasha Mendis & Francesco Rubino & , 2022. "Chemotaxis shapes the microscale organization of the ocean’s microbiome," Nature, Nature, vol. 605(7908), pages 132-138, May.
    4. Jonas Cremer & Tomoya Honda & Ying Tang & Jerome Wong-Ng & Massimo Vergassola & Terence Hwa, 2019. "Chemotaxis as a navigation strategy to boost range expansion," Nature, Nature, vol. 575(7784), pages 658-663, November.
    5. Estelle E. Clerc & Jean-Baptiste Raina & Johannes M. Keegstra & Zachary Landry & Sammy Pontrelli & Uria Alcolombri & Bennett S. Lambert & Valerio Anelli & Flora Vincent & Marta Masdeu-Navarro & Andrea, 2023. "Strong chemotaxis by marine bacteria towards polysaccharides is enhanced by the abundant organosulfur compound DMSP," Nature Communications, Nature, vol. 14(1), pages 1-14, December.
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