IDEAS home Printed from https://ideas.repec.org/a/nat/natcom/v16y2025i1d10.1038_s41467-025-55911-0.html
   My bibliography  Save this article

Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure

Author

Listed:
  • Tess E. Peterson

    (Johns Hopkins University
    University of Minnesota)

  • Virginia S. Hahn

    (Johns Hopkins University)

  • Ruin Moaddel

    (NIH)

  • Min Zhu

    (NIH)

  • Sabina A. Haberlen

    (Johns Hopkins Bloomberg School of Public Health)

  • Frank J. Palella

    (Northwestern University Feinberg School of Medicine)

  • Michael Plankey

    (Georgetown University)

  • Joel S. Bader

    (Johns Hopkins University)

  • Joao A. C. Lima

    (Johns Hopkins University)

  • Robert E. Gerszten

    (Beth Israel Deaconess Medical Center)

  • Jerome I. Rotter

    (The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center)

  • Stephen S. Rich

    (University of Virginia)

  • Susan R. Heckbert

    (University of Washington School of Public Health)

  • Gregory D. Kirk

    (Johns Hopkins Bloomberg School of Public Health)

  • Damani A. Piggott

    (Johns Hopkins Bloomberg School of Public Health
    Johns Hopkins University)

  • Luigi Ferrucci

    (NIH)

  • Joseph B. Margolick

    (Johns Hopkins Bloomberg School of Public Health
    Johns Hopkins University)

  • Todd T. Brown

    (Johns Hopkins Bloomberg School of Public Health
    Johns Hopkins University)

  • Katherine C. Wu

    (Johns Hopkins University)

  • Wendy S. Post

    (Johns Hopkins University
    Johns Hopkins Bloomberg School of Public Health)

Abstract

People living with HIV are at higher risk of heart failure and associated left atrial remodeling compared to people without HIV. Mechanisms are unclear but have been linked to inflammation and premature aging. Here we obtain plasma proteomics concurrently with cardiac magnetic resonance imaging in two independent study populations to identify parallels between HIV-related and aging-related immune dysfunction that could contribute to atrial remodeling and clinical heart failure. We discover a plasma proteomic signature that may in part reflect or contribute to HIV-associated atrial remodeling, many features of which are associated with older age and time to incident heart failure among an independent community-based cohort without HIV. This proteomic profile was statistically enriched for immune checkpoint proteins, tumor necrosis factor signaling, ephrin signaling, and extracellular matrix organization, identifying possible shared pathways in HIV and aging that may contribute to risk of heart failure.

Suggested Citation

  • Tess E. Peterson & Virginia S. Hahn & Ruin Moaddel & Min Zhu & Sabina A. Haberlen & Frank J. Palella & Michael Plankey & Joel S. Bader & Joao A. C. Lima & Robert E. Gerszten & Jerome I. Rotter & Steph, 2025. "Proteomic signature of HIV-associated subclinical left atrial remodeling and incident heart failure," Nature Communications, Nature, vol. 16(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-55911-0
    DOI: 10.1038/s41467-025-55911-0
    as

    Download full text from publisher

    File URL: https://www.nature.com/articles/s41467-025-55911-0
    File Function: Abstract
    Download Restriction: no
    File URL: https://libkey.io/10.1038/s41467-025-55911-0?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    References listed on IDEAS

    as
    1. Grimur Hjorleifsson Eldjarn & Egil Ferkingstad & Sigrun H. Lund & Hannes Helgason & Olafur Th. Magnusson & Kristbjorg Gunnarsdottir & Thorunn A. Olafsdottir & Bjarni V. Halldorsson & Pall I. Olason & , 2023. "Large-scale plasma proteomics comparisons through genetics and disease associations," Nature, Nature, vol. 622(7982), pages 348-358, October.
    2. Anna Egerstedt & John Berntsson & Maya Landenhed Smith & Olof Gidlöf & Roland Nilsson & Mark Benson & Quinn S. Wells & Selvi Celik & Carl Lejonberg & Laurie Farrell & Sumita Sinha & Dongxiao Shen & Ja, 2019. "Profiling of the plasma proteome across different stages of human heart failure," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Amil M. Shah & Peder L. Myhre & Victoria Arthur & Pranav Dorbala & Humaira Rasheed & Leo F. Buckley & Brian Claggett & Guning Liu & Jianzhong Ma & Ngoc Quynh Nguyen & Kunihiro Matsushita & Chiadi Ndum, 2024. "Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development," Nature Communications, Nature, vol. 15(1), pages 1-18, December.
    2. Chirag Krishna & Joshua Chiou & Saori Sakaue & Joyce B. Kang & Stephen M. Christensen & Isac Lee & Melis Atalar Aksit & Hye In Kim & David Schack & Soumya Raychaudhuri & Daniel Ziemek & Xinli Hu, 2024. "The influence of HLA genetic variation on plasma protein expression," Nature Communications, Nature, vol. 15(1), pages 1-15, December.

    More about this item

    Statistics

    Access and download statistics

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-025-55911-0. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Sonal Shukla or Springer Nature Abstracting and Indexing (email available below). General contact details of provider: http://www.nature.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.