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Profiling of the plasma proteome across different stages of human heart failure

Author

Listed:
  • Anna Egerstedt

    (Lund University)

  • John Berntsson

    (Lund University
    Lund University)

  • Maya Landenhed Smith

    (Lund University and Skåne University Hospital)

  • Olof Gidlöf

    (Lund University)

  • Roland Nilsson

    (Karolinska Institutet and Karolinska University Hospital)

  • Mark Benson

    (Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Quinn S. Wells

    (Vanderbilt University)

  • Selvi Celik

    (Lund University)

  • Carl Lejonberg

    (Lund University)

  • Laurie Farrell

    (Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Sumita Sinha

    (Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Dongxiao Shen

    (Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Jakob Lundgren

    (Lund University
    Skåne University Hospital)

  • Göran Rådegran

    (Lund University
    Skåne University Hospital)

  • Debby Ngo

    (Beth Israel Deaconess Medical Center and Harvard Medical School)

  • Gunnar Engström

    (Lund University)

  • Qiong Yang

    (Boston University School of Public Health)

  • Thomas J. Wang

    (Vanderbilt University)

  • Robert E. Gerszten

    (Beth Israel Deaconess Medical Center and Harvard Medical School
    Broad Institute of Harvard and Massachusetts Institute of Technology)

  • J. Gustav Smith

    (Lund University
    Skåne University Hospital
    Broad Institute of Harvard and Massachusetts Institute of Technology
    Wallenberg Center for Molecular Medicine and Lund University Diabetes Center, Lund University)

Abstract

Heart failure (HF) is a major public health problem characterized by inability of the heart to maintain sufficient output of blood. The systematic characterization of circulating proteins across different stages of HF may provide pathophysiological insights and identify therapeutic targets. Here we report application of aptamer-based proteomics to identify proteins associated with prospective HF incidence in a population-based cohort, implicating modulation of immunological, complement, coagulation, natriuretic and matrix remodeling pathways up to two decades prior to overt disease onset. We observe further divergence of these proteins from the general population in advanced HF, and regression after heart transplantation. By leveraging coronary sinus samples and transcriptomic tools, we describe likely cardiac and specific cellular origins for several of the proteins, including Nt-proBNP, thrombospondin-2, interleukin-18 receptor, gelsolin, and activated C5. Our findings provide a broad perspective on both cardiac and systemic factors associated with HF development.

Suggested Citation

  • Anna Egerstedt & John Berntsson & Maya Landenhed Smith & Olof Gidlöf & Roland Nilsson & Mark Benson & Quinn S. Wells & Selvi Celik & Carl Lejonberg & Laurie Farrell & Sumita Sinha & Dongxiao Shen & Ja, 2019. "Profiling of the plasma proteome across different stages of human heart failure," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
    • Handle: RePEc:nat:natcom:v:10:y:2019:i:1:d:10.1038_s41467-019-13306-y
    DOI: 10.1038/s41467-019-13306-y
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    Cited by:

    1. Amil M. Shah & Peder L. Myhre & Victoria Arthur & Pranav Dorbala & Humaira Rasheed & Leo F. Buckley & Brian Claggett & Guning Liu & Jianzhong Ma & Ngoc Quynh Nguyen & Kunihiro Matsushita & Chiadi Ndum, 2024. "Large scale plasma proteomics identifies novel proteins and protein networks associated with heart failure development," Nature Communications, Nature, vol. 15(1), pages 1-18, December.

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