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Glia detect and transiently protect against dendrite substructure disruption in C. elegans

Author

Listed:
  • Katherine C. Varandas

    (The Rockefeller University)

  • Brianna M. Hodges

    (The Rockefeller University)

  • Lauren Lubeck

    (The Rockefeller University
    Hopkins Marine Station of Stanford University)

  • Amelia Farinas

    (The Rockefeller University
    Stanford University)

  • Yupu Liang

    (The Rockefeller University
    Alexion Pharmaceuticals)

  • Yun Lu

    (The Rockefeller University)

  • Shai Shaham

    (The Rockefeller University)

Abstract

Glia assess axon structure to modulate myelination and axon repair. Whether glia similarly detect dendrites and their substructures is not well understood. Here we show that glia monitor the integrity of dendrite substructures and transiently protect them against perturbations. We demonstrate that disruption of C. elegans sensory neuron dendrite cilia elicits acute glial responses, including increased accumulation of glia-derived extracellular matrix around cilia, changes in gene expression, and alteration of secreted protein repertoire. DGS-1, a 7-transmembrane domain neuronal protein, and FIG-1, a multifunctional thrombospondin-domain glial protein, are required for glial detection of cilia integrity, physically interact, and exhibit mutually-dependent localization to and around cilia, respectively. Glial responses to dendrite cilia disruption transiently protect against damage. Thus, our studies uncover a homeostatic, protective, dendrite-glia signaling interaction regulating dendrite substructure integrity.

Suggested Citation

  • Katherine C. Varandas & Brianna M. Hodges & Lauren Lubeck & Amelia Farinas & Yupu Liang & Yun Lu & Shai Shaham, 2025. "Glia detect and transiently protect against dendrite substructure disruption in C. elegans," Nature Communications, Nature, vol. 16(1), pages 1-15, December.
    • Handle: RePEc:nat:natcom:v:16:y:2025:i:1:d:10.1038_s41467-024-55674-0
    DOI: 10.1038/s41467-024-55674-0
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    References listed on IDEAS

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    1. Menachem Katz & Francis Corson & Wolfgang Keil & Anupriya Singhal & Andrea Bae & Yun Lu & Yupu Liang & Shai Shaham, 2019. "Glutamate spillover in C. elegans triggers repetitive behavior through presynaptic activation of MGL-2/mGluR5," Nature Communications, Nature, vol. 10(1), pages 1-13, December.
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